This book presents a comprehensive survey of adipose tissue, its physiological functions, and its role in disease. The volume spans the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical studies. Groundbreaking recent studies are incorporated into traditional models of adipose tissue properties. A description of the role of macrophages in obesity and metabolism in included. Adipose Tissue and Adipokines in Health and Disease presents a comprehensive survey of adipose tissue, its physiological functions, and its role in disease. This volume spans the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical studies. The authors-distinguished researchers, clinicians and epidemiologists-have incorporated groundbreaking recent studies into traditional models of adipose tissue properties. Chapters on well-known properties of adipokines leptin and adiponectin are complemented by an introduction to a novel view of adipose tissue as a dynamic organ that regulates systemic substrate availability and metabolism, along with a variety of other discrete functions. This novel concept is expanded as the role of adipose tissue in maintaining body homeostasis and the modulation of inflammatory and metabolic responses is discussed. Worldwide trends in obesity are discussed from an evolutionary perspective and causes of the current obesity epidemic are postulated. Additionally, researchers and clinicians examine the association and potential role of adipose tissue in disease mediation and offer epidemiological evidence. This volume concludes with a thoughtful and innovative discussion of various approaches to inducing and sustaining weight loss in obese patients and the health effects of such treatments. Adipose Tissue and Adipokines in Health and Disease provides a broad and substantial foundation for understanding new developments in adipose tissue biology and successfully integrating them into new research endeavors.

Klappentext

The aim of Adipose Tissue and Adipokines in Health and Disease is to provide comprehensive information regarding adipose tissue, its physiological functions and its role in disease. This volume contains a collection of information spanning the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical aspects, in one place. This book is indispensable for basic researchers and clinicians interested in the fields of obesity, metabolic diseases, inflammation and immunity, and specialists in each of the pathologies associated with obesity.

Inhalt
Adipose tissue and adipokines in health and disease Editors: Giamila Fantuzzi and Theodore Mazzone Series Editor Page Adrianne Bendich Foreword Andrew P. Goldberg and Susan K. Fried Introduction Giamila Fantuzzi and Theodore Mazzone Adipose tissue: structure and function The adipose organ Saverio Cinti Metabolism of white adipose tissue Michel Beylot Leptin Malaka B. Jackson and Rexford S. Ahima Adiponectin Aimin Xu, Yu Wang and Karen S L Lam Adipokines as regulators of immunity and inflammation Vasoactive factors and inflammatory mediators produced in adipose tissue Gema Frühbeck Regulation of the immune response by leptin Víctor Sánchez-Margalet, Patricia Fernandez-Riejos, Carmen González-Yanes, Souad Najib, Consuelo Martín-Romero and José Santos-Alvarez Leptin in autoimmune disease Giuseppe Matarese Leptin and gastrointestinal inflammation Arvind Batra and Britta Siegmund Adiponectin and inflammation Yuji Matsuzawa Interactions between adipocytes and immune cells Macrophages, adipocytes and obesity Anthony W. Ferrante, Jr Interactions of adipose and lymphoid tissues Caroline M. Pond Adipose tissue and mast cells: adipokines as yin-yang modulators of inflammation George N. Chaldakov, Anton B. Tonchev, Nese Tuncel, Pepa Atannasova and Luigi Aloe Bone marrow adipose tissue Patrick Laharrague and Louis Castella The obesity epidemics Environmental aspects of obesity Lisa Diewald, Myles S. Faith M and Meredith Dolan The genetics of obesity: five fundamental problems with the famine hypothesis John R. Speakman Developmental perspectives on the origins of obesity Cristopher W. Kuzawa, Peter D. Gluckman and Mark A. Hanson The epidemiology of obesity Carol A. Braunschweig Adipose tissue and disease Inherited and acquired lipodystrophies: disorders of adipose tissue development, differentiation and death Vinaja Simha and Anil Agarwal Mechanisms of cachexia Robert H Mak and Wai W Cheung Adipose tissue and insulin resistance Stephen E. Borst Adipokines in non-alcoholic fatty liver disease Ancha Baranova and Zobair M. Younossi Adiposity and cancer Eugenia E. Calle Obesity and cardiovascular disease Alison M. Morris, Paul Poirier and Robert H. Eckel Obesity and asthma Elisabeth Luder Adiposity and kidney disease Srinivasan Beddhu and Bonnie Ching-Ha Kwan Obesity and joint disease Andrew J Teichtahl, Anita E Wluka and Flavia M. Cicuttini Effect of weight loss on disease Sergio Josè Bardaro, Dennis Hong and Lee Swanstrom