The basic mechanism underlying directional differences in excitability, con duction velocity, andsafetyfactor thatleadtocircusmovementreentry incardiac muscle is generally attributed to a spatial difference in the refractory period as originally described by Mines [1] or to a depressed segment as described by Schmitt and Erlanger [2]. A departure from this depolarization in cardiac muscle involve quantities, such as Vmax' that are not directly descriptive of the underlying mechanisms of propagation.

Klappentext

The basic mechanism underlying directional differences in excitability, con­ duction velocity, andsafetyfactor thatleadtocircusmovementreentry incardiac muscle is generally attributed to a spatial difference in the refractory period as originally described by Mines [1] or to a depressed segment as described by Schmitt and Erlanger [2]. A departure from this depolarization in cardiac muscle involve quantities, such as Vmax' that are not directly descriptive of the underlying mechanisms of propagation.

Inhalt
Electrical activation and propagation.- 1. Use of computer simulations for combined experimental-theoretical study of anisotropic discontinuous propagation at a microscopic level in cardiac muscle.- 2. The role of the interstitial space in electrical models of cardiac sources.- 3. Parasympathetic control of the SA node cell in rabbit heart a model.- 4. Effects of the discrete cellular structure on electrical propagation in cardiac tissue.- 5. Electrical field model for electric interactions between myocardial cells.- 6. The role of distributed conduction velocities in simulated epicardial activation maps.- 7. Effects of anisotropy on functional reentrant circuits: preliminary results of computer simulation studies.- 8. Interaction of oscillatory currents and steady-state membrane conductance in isolated cardiac myocytes: experimental description and preliminary modeling of syncytial effects.- 9. General discussion.- Electrical and mechanical interactions.- 10. Influence of pacing site on ventricular mechanics.- 11. Effect of alterations of the left ventricular activation sequence on left ventricular performance.- 12. Effect of the thyroid state on ventricular action potential characterictics in the mammalian heart.- 13. Mechano-electric coupling in myocardium and its possible role in ischaemic arrhythmia.- 14. Tetanization of intact hearts: a new strategy for studying the response of the contractile proteins to calcium.- 15. Modulation properties of myocardial contractile proteins.- 16. Insight into excitation-contraction coupling of heart derived from studies of the force-interval relationship.- 17. Model of Ca release mechanism from the sarcoplasmic reticulum: Ca-mediated activation, inactivation and reactivation.- Microstructure and macroscale mechanics.- 18. Athree dimensional constructive law for the passive myocardium based on a microstructural approach.- 19. 3-D simulation of left ventricular contraction combining myocardial mechanics and electrical activation.- 20. The mechanical effects of the pericardium on the left ventricle.- 21. Conversion of fiber stress to global left ventricular pump work.- Micro to macro coronary circulation.- 22. An analysis of a vascular arborization model for the microcirculation.- 23. Delineating coronary hemodynamic mechanisms by computer simulation.- 24. Distensibility of microvasculature and its consequences on coronary arterial and venous flow.- 25. Impedance to coronary flow.- 26. Intramyocardial blood volume implications for analysis of myocardial mechanical characteristics via in vivo imaging of the heart.- 27. The effect of wall forces on coronary flow.- 28. Experimental validation studies related to clinical applications of cine computed tomography.- Dysfunction of the diseased ventricle: mechanical and metabolic aspects.- 29. Regional ventricular function in myocardial ischemia.- 30. Simulation of the mechanics of an infarcted left ventricle.- 31. Nonischemic dysfunction at the lateral margins of ischemic myocardium.- 32. Assisted circulation as a tool for the stuy of cardiac models and cardiac performance.- 33. Modulation of coronary autoregulatory responses.- 34. Is stunned myocardium energy deficient?.- 35. Concentric left ventricular hypertrophy: a simulation study of mechanics related to transmural oxygen demand and perfusion.- 36. Coronary reserves in myocardial hypertrophy.- Basic phenomena in transport and metabolism.- 37. Making mathematical descriptions of metabolic reaction networks manageable.- 38. Integrated phenomenology of transport, permeation, and metabolicreactions in the heart.- 39. Transport between myocardial capillaries and cardiac lymphatics.- 40. Disturbances in myocardial lipid homeostasis during ischemia and reperfusion.- 41. Heat transfer and temperature profiles during ischemia and infarction in the left ventricular wall.- Clinical implications.- 42. Longterm assessment and management of chronic cardiac failure.- 43. Acute and chronic cardiac failure: the oxygen transport system gone awry.- General discussion.- 44. Interactions: mechanics, metabolism and perfusion.- 45. Relating models to experiments.- Concluding remarks.- Index of subjects.