Zinc Signaling

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

Autorentext
Professor. Toshiyuki Fukada, Ph.D., Faculty of Pharmaceutical Sciences, Molecular and Cellular Physiology, Tokushima Bunri University, Japan.
Associate professor. Taiho Kambe, Ph.D., Department of Applied Molecular Biology, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Japan.

Inhalt
1 Opening The Second Era of Zinc Signaling study 2 Regulation of cellular zinc ions and their signalling functions 3 Zinc transporter proteins-A review and a new view from biochemistry 4 The Metallothionein-Zinc Landscape: How It Shapes Antimicrobial Immunity 5 Role of Zinc signaling in mast cell, basophil, T cell, and B cell 6 The role of Zinc signaling in reproduction 7 Zinc Signaling in Skeletal Muscle 8 Zinc Signaling in Aging Heart Function 9 Zinc signaling in the life and death of neurons 10 Possible therapeutic roles of metallothionein-3 and zinc in endosome-autophagosome-lysosomal pathway (EALP) dysfunction in astrocytes 11 Zinc in neurodegeneration 12 Role of Zinc Transporters in Type 2 Diabetes and Obesity 13 Zinc Signals in Immunology 14 Zinc Signals in Inflammation 15 Zinc transporters and zinc signaling in skin formation and diseases 16 Post-translational mechanisms of zinc signalling in cancer 17 Zinc Signaling (Zinc'in) in Intestinal function 18 In Situ Imaging of Zinc with Synthetic Fluorescent Probes 19 Zinc Signals in biology