As a fundamental biological process, cell death and cell survival is essential to the normal homeostasis of the organism. Our knowledge on this process has been tremendously expanded in the past two decades. Essentials of Apoptosis: A Guide for Basic and Clinical Research was first published in 2003. It timely provided a comprehensive but concise summary of the essential information of apoptosis to both new investigators to the field and seasoned researchers seeking an integrated view of the topics. The past several years have witnessed significant new developments in the field of apoptosis and cell death in general. The concept of various types of cell death has been further developed. The studies in both basic and clinical disciplines have been greatly expanded. Notable progresses have been made in extending the work into the therapeutic arena. As a result, the field has matured considerably and developed extensive crosstalk with works in other fields. The second edition incorporates these new developments, in addition to the basic core concepts and machinery of apoptosis. Multiple new topics are added that expand the coverage on different types of cell death (apoptosis, necrosis, autophagic death and mitotic death), and on different death pathways (mediated by mitochondria, endoplasmic reticulum, death receptors, or lysosome). Furthermore, several integrated topics linking cell death to metabolism, redox status, transcription regulation are included and a systems biology approach to study apoptosis is introduced. Moreover, the roles of apoptosis and cell death in the pathogenesis of many human diseases in every major organ system are explored in details with novel therapeutic outlooks. This edition is the result of the hard work by more than 80 leading experts from across the world.

Authoritative, comprehensive and highly instructive, the second edition of Essentials of Apoptosis should be valuable for both novice and seasoned investigators, asan informative reference as well as a practical guide.

Zusammenfassung

This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.

Inhalt
I. Molecules and Pathways of Apoptosis.- Caspases: Activation, Regulation, and Function.- The Bcl-2 Family Proteins.- The Mammalian IAPs: Multifaceted Inhibitors of Apoptosis.- Structural Biology of Programmed Cell Death.- The Death Receptor Pathway.- The Mitochondrial Pathway: Focus on Shape Changes.- The Endoplasmic Reticulum Pathway.- Reactive Oxygen Species in Cell Fate Decisions.- The Integration of Metabolism and Cell Death.- Transcriptional Regulation of Apoptosis.- Clearance of Apoptotic Cells Mechanisms and Consequences.- Systems Biology Approaches to the Study of Apoptosis.- II: Apoptosis in Model Organisms.- Programmed Cell Death in Plants: Apoptotic but Not Quite.- Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiae.- Programmed Cell Death in C. elegans.- Cell Death in Drosophila.- III. Apoptosis in Mammalian Physiology and Pathogenesis.- Cell Death: Defining and Misshaping Mammalian Embryos.- Matters of Life and Death in the Immune System.- Cell Death in the Hematopoietic System.- Cell Death in Acute Neuronal Injury.- Apoptosis in Neurodegenerative Diseases.- Apoptosis in Cardiovascular Pathogenesis.- Apoptosis in Lung Injury and Disease.- Apoptosis in Liver Injury and Liver Diseases.- Apoptosis in Acute Kidney Injury.- Apoptosis in Cancer Biology and Cancer Therapeutics.- IV. Alternative cell death mechanisms and pathways.- Necrosis: Molecular Mechanisms and Physiological Roles.- Caspase-Independent Mitotic Death.- Lysosomal Proteases in Cell Death.- Autophagy and Cell Death.- V. Approaches to the study of apoptosis.- Analysis of Apoptosis: Basic Principles and Protocols.