The Nutrition and Health series of books has as an overriding mission to provide health professionals with texts that are considered essential because each includes: a synthesis of the state of the science; timely, in-depth reviews by the leading researchers in their respective fields; extensive, up-to-date fully annotated reference lists; a detailed index; relevant tables and figures; identification of paradigm shifts and the consequences; of information between chapters, but targeted, inter-chapter refer­ virtually no overlap rals, suggestions of areas for future research; and balanced, data-driven answers to patient questions that are based on the totality of evidence rather than the findings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter as well as in the choice of chapter authors. The international perspective, especially with regard to public health initiatives, is emphasized where appropriate. The editors, whose training is both research and practice oriented, have the opportunity to develop a primary objective for their book, define the scope and focus, and then invite the leading authori­ ties from around the world to be part of their initiative. The authors are encouraged to provide an overview of the field, discuss their own research, and relate the research de findings to potential human health consequences.

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Evolution, Biologic Functions, and Recommended Dietary Allowances for Vitamin D, Michael F. Holick. Photobiology of Vitamin D, Tai C. Chen. Functional Metabolism and Molecular Biology of Vitamin D Action, Laura C. McCary and Hector F. DeLuca. Metabolism and Catabolism of Vitamin D, Its Metabolites, and Clinically Relevant Analogs, Glenville Jones. The Enzymes Responsible for Metabolizing Vitamin D, Kyu-Ichiro Okuda and Yoshihiko Ohyama. The Vitamin D Binding Protein and Its Clinical Significance, John G. Haddad. Molecular Biology of the Vitamin D Receptor, Paul N. MacDonald. Vitamin D Receptor Translocation, Julia Barsony. Molecular Recognition and Structure-Activity Relations in Vitamin D-Binding Protein andVitamin D Receptor, Rahul Ray. Mechanisms of Action of 1,25-Dihydroxyvitamin D3 on Intestinal Calcium Absorption and Renal Calcium Transport, Mihali Raval-Pandya, Angela R. Porta, and Sylvia Christakos. Biologic and Molecular Effects of Vitamin D on Bone, Jane B. Lian, Ada Staal, André van Wijnen, Janet L. Stein, and Gary S. Stein. Nongenomic Rapid Effects of Vitamin D, Daniel T. Baran. Noncalcemic Actions of 1,25-Dihydroxyvitamin D3 and Clinical Implications, Michael F. Holick. Regulation of Parathyroid Hormone Gene Expression and Secretion by Vitamin D, Tally Naveh-Many and Justin Silver. Vitamin D Assays and Their Clinical Utility, Ronald L. Horst and Bruce W. Hollis. Rickets and Vitamin D Deficiency, Michèle Garabédian and Hanifa Ben-Mekhbi. Vitamin D and Bone Health in Adults and the Elderly, Clifford J. Rosen. Inherited Defects of Vitamin D Metabolism, Marie Demay. Molecular Defects in the Vitamin D Receptor Associated with Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets, Peter J. Malloy and David Feldman. Extrarenal Production of 1,25-Dihydroxyvitamin D and Clinical Implications, John S. Adams. Clinical Utility of 1,25-Dihydroxyvitamin D3 and Its Analogs for the Treatment of Psoriasis and Other Skin Diseases, J. Reichrath and Michael F. Holick.Epidemiology of Cancer Risk and Vitamin D, Cedric F. Garland, Frank C. Garland, and Edward D. Gorham. Chemotherapeutic and Chemopreventive Actions of Vitamin D3 Metabolites and Analogs, Thomas A. Brasitus and Marc Bissonnette. Vitamin D and Breast Cancer, Johannes P. T. M. van Leeuwen, Trudy Vink-van Wijngaarden, and Huibert A. P. Pols. Anticancer Activity of Vitamin D Analogs, Milan R. Uskokovic`, Candace S. Johnson, Donald L. Trump, and Robert H. Getzenberg. Index.