Vascular Endothelium in Health and Disease

In recent years there has been rapid progress in research on vascular endothelium. This has led to significant advances in our understanding of the structure and function of vascular endothelium in health and disease, including such aspects as the permeability of endothelium in relation to its ultrastructural correlates, theoretical basis, regulatory factors, and role in atherogenesis; the interaction between endothelium and blood cells; the endothelial release and processing of a number of important physiological agents, such as eicosanoids, hemostatic factors, and histamine; the cell biology of endothelium with respect to the cytoskeletal apparatus, cell activation, and cell locomotion; and the role of endothelium in microcirculatory regulation in normal and pathophysiological circumstances. A Symposium on "Vascular Endothelium in Health and Disease" was held on August 5-6, 1987, at the Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China, following the 4th World Congress for Microcirculation in Japan. Experts working on various aspects of vascular endothelium came from allover the world to participate in this two-day Symposium and gave excellent presentations. This volume, embodying the proceedings of that Symposium, is a collection of the papers given by the speakers with, in many cases, further updating and new information added subsequent to the Symposium. The Institute of Biomedical Sciences (IBMS), the site of this Symposium, is a newlJl established research institution, which has vascular endothelium as one of its areas of research emphasis.

Inhalt

Microvascular Permeability.- The Paracellular Pathway in Capillary Endothelia.- Theoretical Modeling of Fluid Transport Through Endothelial Junctions.- Variability in Microvascular Estimates of Capillary Surface Area for Exchange.- Atrial Natriuretic Peptide (ANP)-Induced Increase in Capillary Albumin and Water Flux.- Role of Endothelium in Atherogenesis.- Computerized 3-D Reconstruction of Small Blood Vessels from High Voltage Electron-micrographs of Thick Serial Cross Sections.- Correlation of Laser-Doppler-Velocity Measurements and Endothelial Cell Shape in a Stenosed Dog Aorta.- Role of Hemodynamic Factors in Atherogenesis.- The Role of Arterial Endothelial Cell Mitosis in Macromolecular Permeability.- Leukocyte-Endothelium Interactions.- The Ultrastructural Basis of Interactions between Leukocytes and Endothelium.- Leukocyte Endothelium Adhesion and Microvascular Hemodynamics.- White Cell-Endothelium Interaction during Postischemic Reperfusion of Skin and Skeletal Muscle.- Morphometric Studies on Human Leukocyte Granules.- Prostaglandins and Hemostatic Functions of Vascular Endothelium.- Effect of Vitamin E on Prostacyclin Production from Cultured Aortic Endothelial Cells.- Prostacyclin Production in Vascular Endothelium of Patients with Blackfoot Disease.- Endothelial Cell Function in Hemostasis and Thrombosis.- Microcirculatory Disturbances in Endotoxin-Induced Disseminated Intravascular Coagulation.- Histamine and Endothelium.- Changing Sensitivity to H, and H2 Receptor Agonists in the Growing Vasculature.- Radioautographic Characterization of H1 and H2 Receptor Antagonists.- Alterations in Gastric Mucosal Microvascular Endothelium in a Stressed Condition-Relevance to Gastric Ulcerogenesis.- Cell Biology of Endothelium.- Carbohydrate Regulated Transendothelial Transport of Proteins.- Computer Tracking of Endothelial Activation Responses.- Effects of Cytochalasin B on the Primary Cultured Capillary Endothelium.- Tumor Microcirculation.- Capillary Ultrastructure and Microcirculatory Function of Malignant Tumors.- Transvascular and Interstitital Transport in Tumors.- Matrix Control of Tumor Angiogenesis.