Treatment of Acute Leukemias

Although much progress has been made in the treatment of acute leukemia, there is still vigorous debate over the optimal methods for securing additional gains in event-free survival and for reducing the toxic side effects of "curative" therapy. In Treatment of Acute Leukemias: New Directions for Clinical Research, international experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for newly diagnosed and relapsed acute lymphoblastic and myeloid leukemia in children, adolescents, and adults. Among the therapies considered are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy. Problems of central-nervous-system therapy, minimal residual disease, drug resistance, and directions of future research are also considered. Discussion of each major topic by two distinguished groups of investigators ensures broad and balanced coverage.
Comprehensive and up-to-date, Treatment of Acute Leukemias: New Directions for Clinical Research offers oncologists practical guidelines for precise diagnosis and optimal treatment of childhood and adult acute leukemia, as well as insights into those aspects of patient management most in need of further study and refinement.

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Part I: Diagnosis, Classification, and Prognosis Classification of Acute Leukemias: Perspective 1 Wolf-Dieter Ludwig, Torsten Haferlach, and Claudia Schoch Classification of Acute Leukemias: Perspective 2 Frederick G. Behm Part II: Chemotherapeutic Strategies A. Infant Leukemias Biology and Treatment of Infant Leukemias: Perspective 1 Rob Pieters Biology and Treatment of Acute Leukemias in Infants: Perspective 2 Gregory H. Reaman B. Childhood Acute Lymphoblastic Leukemia Treatment of Childhood Acute Lymphoblastic Leukemia Martin Schrappe and Martin Stanulla Treatment of Childhood Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute ALL Consortium Perspective Lewis B. Silverman and Stephen E. Sallan C. Acute Lymphoblastic Leukemia in Adolescents and Young Adults Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: Lessons Learned and Future Directions Sima Jeha and Hagop M. Kantarjian Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia: Children's Cancer Group Trials James Nachman D. Acute Lymphoblastic Leukemia in Adults Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 1 Spero R. Cataland and Richard A. Larson Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 2 Dieter Hoelzer and Nicola Gökbuget E. Central Nervous System Therapy for Acute Lymphoblastic Leukemia Central Nervous System-Directed Therapy for Acute Lymphoblastic Leukemia Judith M. Chessells Diagnosis, Prophylaxis, and Treatment of Central Nervous System Involvement in Acute Lymphoblastic Leukemia Anjo J. P. Veerman F. Relapsed Acute Lymphoblastic Leukemia Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 1 Helmut Gadner, Georg Mann,and Christina Peters Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 2 Günter Henze and Arend von Stackelberg G. B-Cell Acute Lymphoblastic Leukemia Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 1 Catherine Patte Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 2 John T. Sandlund H. Acute Myeloid Leukemia in Children Treatment of Acute Myeloid Leukemia in Children Ursula Creutzig Treatment of Childhood Acute Myeloid Leukemia David M. Loeb and Robert J. Arceci I. Acute Myeloid Leukemia in Adults Therapy of Acute Myeloid Leukemia in Adults Bob Löwenberg Treatment of Adult Acute Myelogenous Leukemia Ricardo T. Spielberger and Stephen J. Forman J. Acute Promyelocytic Leukemia Acute Promyelocytic Leukemia: Perspective 1 Zhu Chen and Zhen-Yi Wang Acute Promyelocytic Leukemia: Perspective 2 Francesco Lo Coco, Giuseppe Avvisati, and Franco Mandelli K. Childhood Leukemias in Underprivileged Countries Treatment of Childhood Leukemias in Underprivileged Countries Bharat Agarwal and Rashmi Dalvi How to Confront the Problem of Treatment of Childhood Leukemias in Underprivileged Populations Giuseppe Masera and Andrea Biondi Part III: Antileukemic Drugs A. High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia Rationale for High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia Timothy L. Brenner and William E. Evans Role of Methotrexate in the Treatment of Acute Lymphoblastic Leukemia Bruce M. Camitta and Barton A. Kamen B. Asparaginase Asparaginase Barbara L. Asselin and Joanne Kurtzberg Asparaginase Treatment Carmelo Rizzari C. Antipurines in Childhood Acute Lymphoblastic