Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics

This book presents concise chapters written by internationally respected experts on various important aspects of translational cancer genomics, offering a comprehensive overview of the onco-omics applications in the new era of cancer personal genomics research field. Being a complex disease that affects millions of people worldwide, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. In the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient's specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and even more, considering the immune system, the metabolism and in the near future the microbiome, all areas nowadays related in the prognosis and treatment of cancer patients. These contributionsare either critical reviews or clinical and basic research reports. The topics discussed here include evidence-based medicine and provides useful information on translational cancer research to clinicians and biomedical scientists in order to offer another vision of cancer origin beyond the traditional causes or the oncogenic maintenance concept proposed by the oncogene addiction theory.

Zusammenfassung

Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient's specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.

Inhalt
Preface

1. Pharmaco-Geno-Proteo-Metabolomics and Translational Research in Cancer.

Edith A. Fernández-Figueroa, Jorge E. Peña Velasco, Claudia Rangel-Escareño

2. Next generation sequencing (NGS): a revolutionary technology in pharmacogenomics and personalized medicine in Cancer. Stefania Morganti, Paolo Tarantino, Emanuela Ferraro, Paolo D'Amico, Bruno Achutti Duso and Giuseppe Curigliano

3. Pharmaco-epigenomics: on the road of translation medicine

César López-Camarillo, Dolores Gallardo Rincón, María Elizbeth Alvarez-Sánchez, Laurence A. Marchat

4. Design and Implementing Pharmacogenomics Study in Cancer

Francisco Emilio Vera Badillo MD, MSc, María Luisa Romero Lagunes MD

5. Onco-omics approaches and applications in Clinical Trials for Cancer patients.

Juan-Manuel Hernandez-Martinez, Roberto Sánchez-Reyes, JG. De la Garza-Salazar, Oscar Arrieta

6. Issues and Ethical Considerations in Pharmaco-oncogenomics.

Gilberto Morgan

7. Pharma-oncogenomics in the era of personal genomics: a quick guide to online resources and tools.

Rohan P. Joshi, David F. Steiner, Eric Q. Konnick, and Carlos J. Suarez

8. Inmuno-Oncology in the era of Personalized Medicine

William R. Gwin III, Mary L. Disis, and Erika Ruiz-Garcia

9. CAR T Cell and Personalized Medicine

Marlid Cruz-Ramos, Jesús García-Foncillas

10. Oncobiome at the forefront of a novel molecular mechanism to understand the Microbiome and Cancer

Horacio Astudillo-de la Vega, Oscar Alonso-Luna, Jóse Ali-Pérez, César López-Camarillo, Erika Ruiz-García

11. Nutrition, Cancer and Personalized Medicine Jóse Ali-Pérez, Abelardo Meneses Garcia, Fabiola de la Rosa
Index.