This 1987 ORPRC Symposium on Primate Reproductive Biology, the third in a series, marked the twenty-fifth anniversary of the Oregon Regional Primate Research Center (ORPRC). In organizing these symposia, we have emphasized the dedication of many ORPRC staff members to research with nonhuman primates as models for human reproduction. The first symposium in this series, organized by William Montagna, was held in May 1981. Appropriately for a beginning series, its topic was fetal endocrinology. The subject of this year's symposium was the primate ovary, and, as in the past, scientists from around the world, including Sweden, Scotland, England, West Germany, and India met in Beaverton, Oregon, to exchange ideas and information on this important "aspect of reproduction. The international scope of the symposium reflects our belief that both the problems and their solutions extend beyond national boundaries. Many of the nonhuman primates that we rely on as models are endangered as civilization, through population pressure, encroaches on their natural habitats. Without a deeper understanding of how primate reproduction is regulated, and without the control over human population that such an understanding can bring, the quality of life for all primate species may well become substantially diminished. Consequently, we dedicate these symposia to the thesis that a deeper understanding of primate reproductive biology will ultimately improve all primate life. Robert M. Brenner Charles H. Phoenix vii PREFACE Today there is renewed interest in the processes controlling the gametogenic and endocrine functions of the ovary.

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I. Folliculogenesis.- 1. Follicle Maturation and Atresia: Morphological Correlates.- 2. Regulation of Follicle Development by Gonadotropins and Growth Factors.- 3. Recent Advances in Inhibin Research.- 4. Follicle Regulatory Protein: An Intraovarian Regulator of Follicular Response to Gonadotropin Stimulation.- 5. Granulosa Cell Differentiation in Primate Ovaries: The Marmoset Monkey (Callithrix jacchus) as a Laboratory Model.- II. Ovulation and Superovulation.- 6. Factors Controlling Mammalian Oocyte Maturation.- 7. Regulation of Ovulatory Processes.- 8. Angios in the Ovary.- 9. Oocyte Maturation and In Vitro Fertilization in the Rhesus Monkey.- 10. Perspectives on Ovarian Stimulation and In Vitro Fertilization in Primate Models.- III. Corpus Luteum Function.- 11. Luteotropic Actions of LH on the Macaque Corpus Luteum.- 12. Luteolysins and Mechanisms of Luteolysis.- 13. The Role of Prostaglandins and Catecholamines for Human Corpus Luteum Function.- 14. Regulation of the Primate Corpus Luteum During Early Pregnancy.- IV. Corpus Luteum Function (Continued).- 15. The Production and Function of Ovarian Relaxin.- 16. Receptor-Mediated Differences in the Actions of Ovine Luteinizing Hormone vs. Human Chorionic Gonadotropin.- 17. The Primate Ovary: Critique and Perspectives.- Keynote Address: Scientific, Legal and Ethical Issues in Reproductive Research.- Speakers and Chairmen.- Author Index.