To function properly, neurons must interact with other constituent elements of the brain (e.g., blood supply and myelin), and in fact most diseases of the nervous system involve these nonneuronal components. In The Neuronal Environment: Brain Homeostasis in Health and Disease, leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, ion homeostasis, and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system, which controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in blood-brain barrier function, and inflammation and the neuroimmune system. All these elements are treated in the context of their importance for neurons and the major diseases affecting them.
Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates for today's neuroscientists, cell biologists, and pharmacologists a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the brain's sole information processing system.

Klappentext

Leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, as well as on both ion and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system that controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in neuronal demand and in blood-brain barrier function, and inflammation and the neuroimmune system. Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the only information processing system in the brain.

Inhalt

I. Neuronal Activity and Its Dependence on the Microenvironment Central Nervous System Microenvironment and Neuronal Excitability Stephen Dombrowski, Imad Najm, and Damir Janigro Neuronal Energy Requirements Avital Schurr II. Brain Microenvironment Plasticity of the Extracellular Space Eva Syková Transmitter-Receptor Mismatches in Central Dopamine, Serotonin, and Neuropeptide Systems: Further Evidence for Volume Transmission Anders Jansson, Laurent Descarries, Virginia Cornea-Hébert, Mustapha Riad, Daniel Vergé, Mircea Bancila, Luigi Francesco Agnati, and Kjell Fuxe The Extracellular Matrix in Neural Development, Plasticity, and Regeneration Jeremy Garwood, Nicolas Heck, Franck Rigato, and Andreas Faissner Homeostatic Properties of Astrocytes Wolfgang Walz and Bernhard H. J. Juurlink Glutamate-Mediated Astrocyte-Neuron Communication in Brain Physiology and Pathology Micaela Zonta and Giorgio Carmignoto Axonal Conduction and Myelin Jeffrey D. Kocsis Coupling of Blood Flow to Neuronal Excitability Albert Gjedde III. Brain Macroenvironment Choroid Plexus and the Cerebrospinal-Interstitial Fluid System Roy O. Weller The Blood-Brain Barrier Richard F. Keep Circumventricular Organs James W. Anderson and Alastair V. Ferguson Glial Linings of the Brain Marc R. Del Bigio IV. Immune System-Neuron Interactions Microglia in the CNS Sophie Chabot and V. Wee Yong Invasion of Ischemic Brain by Immune Cells Hiroyuki Kato and Takanori Oikawa