Written cases provide a thoughtful review of modern management and contemplation of the literature, much more so than even a case presentation without the patient. As a result, in recent years the written or prepared case has become the ideal forum for demonstrating how to manage a medical problem to the greatest benefit of the patient. In A Case-Based Guide to Clinical Endocrinology, distinguished clinicians provide stimulating instruction and insights into a wide variety of endocrine subjects, teaching readers modern management of the conditions described and offering targeted entry into the literature. Importantly, many of the important elements in the current curriculum for clinical endocrine training as recommended by the Association of Program Directors in Clinical Endocrinology, Diabetes and Metabolism are covered in this text. To reinforce learning and retention of knowledge, each author has also provided multiplechoice questions following the case studies. Students, residents, fellows, and practitioners will find these examples to be an efficient way to review their understanding and increase their skills and abilities in patient investigation and management.

In all, A Case-Based Guide to Clinical Endocrinology offers a comprehensive volume of concise case-studies that will prove to be of significant importance to all clinicians practicing in this field.

Zusammenfassung
In December 2005 I changed my mind [1]. Up until that time I had put my name on one case history in 400 publications [2]. I changed my mind and realized that reading case histories could be a good learning exercise. I had previously considered useful case histories to be essentially live case demonstrations. Indeed, I had persuaded years of endocrine clinical fellows that writing case histories was not something to be encouraged. But the cheese moved. Livecase historypresentationsbecametoo complexforeasy digestibility. Themany investigations and vast literature review required more contemplation than a live presentation had required in the past. And writing these exercises as a formal case history allowed the complex literature to be better understood. Furthermore, as our evidencebase hasgrown,theidiosyncraticapproachso commoninlivecase dem- strations of the past has become totally unacceptable. The written or prepared case has become the ideal forum for demonstrating how to manage a medical case to the greatest bene?t of the patient. Indeed, written case histories are clearly the very best means of showing medical care guidelines in real practiceandofrevealingtheiradvantagesanddisadvantages[3]. Thatdoesnotmean we should no longer give live case demonstrations. Demonstrating a supportive and knowledgeable patient can be a magni?cent teaching tool. For many years I have presentedendocrinologycasesto our?rst-yearmedicalstudents,andformanyyears these physicians later told me how much they enjoyed them and that they remember them well. So clearly, both formats of delivery remain effective.

Inhalt
The Pituitary Gland.- Pituitary Apoplexy.- When and How to Stop Cabergoline Treatment in Microprolactinomas.- Cushing's Disease.- Thyroid Overactivity.- Amiodarone-Induced Hyperthyroidism.- Interferon-Induced Hyperthyroidism.- Subclinical Hyperthyroidism Due to a Multinodular Thyroid.- Subacute (De Quervain's) Thyroiditis.- Thyroid Underactivity.- Amiodarone-Induced Hypothyroidism.- Autoimmune Hypothyroidism with Persistent Elevation of TSH.- Hashimoto's Thyroiditis and Type 1 Diabetes.- Thyroid Cancer.- Papillary Thyroid Cancer.- Metastatic Papillary Thyroid Cancer.- Medullary Thyroid Cancer.- Follicular Thyroid Carcinoma with Pulmonary and Osseous Metastases.- Adrenal.- Adrenal Insufficiency.- Cushing's Syndrome.- An Incidentally Discovered Adrenal Mass.- Hyperparathyroidism.- Differentiation of Primary Hyperparathyroidism for Familial Benign Hypocalciuric Hypercalcemia.- Management and Investigation of Acute Hypercalcemia.- Evaluation of Complex Primary Hyperparathyroidism.- Evaluation of Hypercalcemia in Infancy.- Metabolic Bone Diseases.- Osteoporosis Due to Hormonal Withdrawal: Common Mistakes.- Osteomalacia: A Cause of Bisphosphonate Failure.- Unusual Manifestations of Paget's Disease of Bone.- Solid Organ Transplantation, Chronic Renal Impairment, and Skeletal Complications.- Endocrine Disorders of Males.- Congenital Isolated Hypogonadotropic Hypogonadism.- Klinefelter Syndrome.- Low Testosterone in Obesity and Type 2 Diabetes.- Female Reproduction.- Central Hypogonadism.- Premature Ovarian Failure.- Oligomenorrhea and Hyperandrogenemia.- Pregnancy.- Hypertension in Pregnancy and Women with Child-Bearing Potential.- Hashimoto's Hypothyroidism During Pregnancy.- Type I Diabetes Mellitus During Pregnancy.- Type 1 Diabetes.- Type 1 Diabetes Onset with Ketoacidosis and Suspected Cerebral Edema.- En Passant Diagnosis of Type 1 Diabetes in Infancy.- Type 1 Diabetes and Comorbidity of Addison's Disease.- Type 2 Diabetes.- Exenatide in Type 2 Diabetes: Indications and Initiation.- Insulin Therapy in the Management of Diabetes Mellitus Type 2.- Treatment of Type 2 Diabetes Mellitus with~Oral~Agents.- Lipid Abnormalities.- Combination Drug Therapy in a Case of Severe Hypercholesterolemia.- A Young Man with Abdominal Pain and Very High Triglycerides: The Chylomicronemia Syndrome.- Roughly Equivalent Lipids in a Middle-Aged Obese Man at Risk for Coronary Disease.- Obesity and the Metabolic Syndrome.- Metabolic Syndrome.- Polycystic Ovarian Syndrome.- Bariatric Surgery.- Puberty.- Amenorrhea.- Early Puberty and Hyperthyroidism.- Hypothalamic Hamartoma.- Leydig Cell Adenoma.- Prolactinoma.- Turner Syndrome.- Instructive Rarities.- Hypothalamic Damage and Obesity.- Systemic Mastocytosis.- Testosteronoma.