It has become increasingly clear over the past several years that Polycystic Ovary Syndrome (PCOS) is a complex genetic disease resulting from the interaction of susceptibility genes and environmental factors.

This book includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. This expert opinion remains critical to guiding practice in PCOS because sufficient data for evidence-based guidelines remains scarce.

Klappentext

All four editors of this title are extremely prominent in the field of PCOS. Although they are all U.S.-based, they are internationally renowned. The book includes the latest diagnostic criteria for PCOS, and comprises the most up to date information about the genetic features and pathogenesis of PCOS.

The diagnostic criteria for PCOS took shape in 1990 following an NIH conference co-organized by Dr. Dunaif, resulting in her classic volume, Polycystic Ovary Syndrome (1992). That title recommended diagnostic criteria of hyperandrogenism and chronic anovlulation with the exclusion of specific disorder of the ovary, adrenal, and pituitary. These criteria dominated the field but were revised in 2003 by a working group of international experts at a conference in Rotterdam. Since then, it has become increasingly clear over the past several years that PCOS is a complex genetic disease resulting from the interaction of susceptibility genes and environmental factors. This volume critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. Additional familial phenotypes of PCOS and their potential genetic basis are also discussed. In all, this title is comprehensive and replete with the latest in expert recommendations on PCOS. This expert opinion remains critical to guiding practice in PCOS because sufficient data for evidence-based guidelines remains scarce.

Inhalt
Folliculogenesis in Polycystic Ovaries.- Accounting for the Follicle Population in the Polycystic Ovary.- What Is the Appropriate Imaging of the Polycystic Ovary.- Polycystic Ovary Versus Polycystic Ovary Syndrome.- Genetic Analyses of Polycystic Ovary Syndrome.- Fetal Origins of Polycystic Ovary Syndrome.- Pubertal Precursors of the Polycystic Ovarian Syndrome.- Variations in the Expression of the Polycystic Ovary Syndrome Phenotype.- Acquired Polycystic Ovary Syndrome.- Recommendations for the Early Recognition and Prevention of Polycystic Ovary Syndrome.- Insulin Action and Secretion in Polycystic Ovary Syndrome.- Polycystic Ovary Syndrome and the Metabolic Syndrome Long-Term Risks.- Insulin Sensitizers Targeting Metabolic and Reproductive Consequences in Polycystic Ovary Syndrome.- Mechanisms and Treatment of Obesity in Polycystic Ovary Syndrome.- Metabolic and Endocrine Effects of Statins in Polycystic Ovary Syndrome.- Recommended Therapies for Metabolic Defects in Polycystic Ovary Syndrome.- Pathogenesis of Hyperandrogenism in Polycystic Ovary Syndrome.- Recommended Treatment Modalities for Hyperandrogenism.- Effective Regimens for Ovulation Induction in Polycystic Ovary Syndrome.- Pregnancy in Polycystic Ovary Syndrome.- Impact of Diagnostic Criteria.