Targeting Trafficking in Drug Development

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

Inhalt
Preface1. Intracellular trafficking of gonadotropin receptors in health and disease. (Ulloa-Aguirre et al)2. Investigating internalization and intracellular trafficking of GPCRs. (Simon R. Foster and Hans Bräuner-Osborne) 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors. (Bernard Mouillac and Christiane Mendre)4. Targeting of disordered proteins by small molecules in neurodegenerative diseases. (Francesca Longhena, PierFranco Spano, Arianna Bellucci5. Pharmacoperones for misfolded gonadotropin receptors. (Claire L. Newton and Ross C. Anderson)6. Pharmacological chaperones: Beyond conformational disorders. (Nancy J. Leidenheimer)7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer. Isabel Betancor, (David J. Timson, Eduardo Salido, Angel L. Pey)8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches. (Meritxell B. Cutrona, Niamh E. Morgan, Jeremy C. Simpson)9. Conserved oligomeric Golgi and neuronal vesicular trafficking. (Leslie K. Climer, Rachel D. Hendrix, Vladimir V. Lupashin)10. SLC6 transporter folding diseases and pharmacochaperoning. (Michael Freissmuth, Thomas Stockner, Sonja Sucic)11. The molecular physiopathogenesis of islet amyloidosis. (Diti Chatterjee Bhowmick, Sanghamitra Singh, Saurabh Trikha, Aleksandar M. Jeremic)12. Folding defects leading to primary hyperoxaluria. (Elisa Oppici, Mirco Dindo, Carolina Conter, Carla Borri Voltattorni, Barbara Cellini)13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. (Tomas Majtan, Angel L. Pey, Paula Gimenez-Mascarell, Luis Alfonso Martínez-Cruz, Csaba Szabo, Victo Kosich, Jan P. Kraus)