Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis

Truly unique cutting edge state of the art information on basic and clinical research.

A great help for the clinician to diagnose and treat this uncommon hormone resistance.

Basic scientists learn how much has been discovered on the mechanism of hormone action from the mutations of the various genes involved to thyroid hormones and TSH.

Inhalt

Preface. 1. Molecular basis of thyroid hormone action; P.M. Yen. 2. Tissues specific action of thyroid hormones: insights from knock out animal models; M. Plateroti, C. Angelin-Duclos, F. Flamant, J. Samarut. 3. Learning from nature's experiments on the thyroid hormone receptor; X-ray structures of RTH mutant ligand-binding domains; B.H. Sandler, J.D. Baxter, R.J. Fletterick. 4. Molecular pathogenesis of resistance to thyroid hormone; V.K.K. Chatterjee. 5. Syndromes of resistance to thyroid hormone: clinical aspects; D. Mannavola, P. Beck-Peccoz. 6. Resistance to thyroid hormone in the absence of mutations in the thyroid hormone receptor genes; S. Refetoff, P.M. Sadow, S. Reutrakul, K. Dennis, D. Mannavola, J. Pohlenz, R.E. Weiss. 7. Lessons learned from TR-beta mutant mice; F.E. Wondisford. 8. Towards the rational design of hormone analogs which complement receptor mutations; J.T. Koh, M.C. Putnam. 9. Multi-factorial regulation of in vivo action of TRbeta mutants. Lessons learned from RTH mice with a targeted mutation in the TRbeta gene; Sheue-yann Cheng. 10. The effect of vitamin A, retinoids and retinoid receptors on the hypothalamic-pituitary-thyroid axis; B.R. Haugen. 11. Pituitary resistance to thyroxine action due to a defect in the type 2 deiodinase; V.A. Galton. 12. Different forms of resistance to thyrotropin (TSH) action; L. Persani, D. Calebiro, T. de Filippis. Index.