Somatostatin

• Each chapter is written by expert(s) active in somatostatin research (experimental and/or clinical)

• It will serve as the only single one-stop source of the most up to date information on the basic and clinical aspects of the biology of somatostatin

Inhalt

Preface; C.B. Srikant. Note on Nomenclature; C.B. Srikant. Contributors. Somatostatin - General Biology. 1. Somatostatin Gene Structure and Regulation; M. Vallejo. 2. Processing and Intracellular Targeting of Somatostatin; R. Mouchantaf, Y.C. Patel, U. Kumar. 3. Cortistatin - A Novel Member of the Somatostatin Gene Family; V. Fabre, A.D. Spier, R. Winsky-Sommerer, J.R. Criado, L. de Lecea. 4. Molecular Evolution of Somatostatin Genes; H. Tostivint, M. Trabucchi, M. Vallarino, J.M. Conlon, I. Lihrmann, H. Vaudry. 5. Altered Patterns of Growth Hormone Secretion in Somatostatin Knockout Mice; M.J. Low, M. Rubinstein, V. Otero-Corchon. Expression and Function of Somatostatin Receptors. 6. Somatostatin Receptor Gene Family - Subtype Selectivity for Ligand Binding; J.P. Hannon, C. Bruns, G. Weckbecker, D. Hoyer. 7. Expression of Somatostatin Receptors in Human Tissues in Health and Disease; J.C. Reubi, B. Waser, J.-C. Schaer. 8. Coexpression of Multiple Somatostatin Receptors in Individual Cells; R. Gardette, F. Petit, S. Peineau, C. Lanneau, J. Epelbaum. 9. Somatostatin Receptor Subtype Selectivity for Cytotoxic and Cytostatic Signaling; C.B. Srikant. 10. Somatostatin Receptor Signaling via Protein Tyrosine Phosphatases; H. Lahlou, J. Guillermet, F. Vernejoul, S. Pyronnet, C. Bousquet, L. Buscail, C. Susini. 11. Expression and Function of Somatostatin and Its Receptors in Immune Cells; D.E. Elliott. 12. Physiology of Somatostatin Receptors: From Genetics to Molecular Analysis; H.-J. Kreinkamp, Chong Wee Liew, D. Bächner, M.-G. Mameza,M. Soltau, A. Quitsch, M. Christenn, W. Wente, D. Richter. Applications in Disease. 13. Somatostatin Receptor Imaging; D.J. Kwekkeboom, M. de Jong, E.P. Krenning. 14. Somatostatin Analogs in the Treatment of Pituitary Tumors; A. Colao. 15. Somatostatin Receptor Targeted-Radio-Ablation of Tumors; M. de Jong, R. Valkema, D.J. Kwekkeboom, E.P. Krenning. 16. Somatostatin Analogue Therapy of Neuro-Endocrine Gastro-Entero Pancreatic Tumors; K. Öberg. 17. Vascular Effects of Somatostatin; P. Häyry, E. Aavik. 18. The Use of Somatostatin Analogues in Diabetic Retinopathy; L.E.H. Smith, M.B. Grant. The Future. 19. Somatostatin and Its Receptors: Past, Present and the Future; C.B. Srikant. Index.