Respiratory System

This is the second edition of a monograph which provided a concise approach to an understanding of the spontaneous and induced lesions in the respiratory system of laboratory animals, especially the rat, mouse, and hamster. This expanded edition keeps the basic format of the first edition but provides much more information applicable to the study of toxicologic pathology. For example, the effects of inhaled toxicants of the upper respiratory tract are presented in detail in relation to the specific cells affected, based upon their precise morphology and function discerned at the ultrastructural level. This approach is followed through the entire volume, with precise identification of the cells preceding consideration of perturbations caused by toxicants of other etiologic agents. Current understanding of the nature and significance of pathologic lesions is probed throughout the volume. Although toxicologic pathology is emphasized, experimental pathologists and other scientists will find this book especially useful.

Klappentext

Approximately ten years have elapsed since the second volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Respiratory System, was first completed. New in­ formation of interest to pathologists has developed at a rather remark­ able pace during these years. Exceptional progress has been made in the routine identification of enzymes and cell products in respiratory cells. A better understanding has developed on the functions of cells of the respiratory tract and of the mechanisms involved in cell metabolism, particularly those involving toxins and carcinogens. Clear concepts have developed concerning the significance of pathologic lesions, particularly in the upper respiratory tract and their relation to human health and risk assessment. Standardized nomenclature has developed significantly dur­ ing the lO-year period since the first edition and is being utilized on an international basis. This has resulted in significant improvement in com­ munication of pathologic data to regulatory agencies and in scientific publications worldwide. This monograph series and others sponsored by ILSI have had significant effects on these improved communications and the international acceptance of standardized nomenclature. In this sec­ ond edition, new formats have been used where more appropriate for the subjects to be covered.

Inhalt

The Upper Respiratory System.- Histology, Ultrastructure, Embryology, Function.- Normal Morphology of the Nasal Passages in Laboratory Rodents.- Proliferative and Metaplastic Lesions in Nonolfactory Nasal Epithelia Induced by Inhaled Chemicals.- Nonneoplastic Lesions of the Olfactory Mucosa.- Microscopic Anatomy of Toxicologically Important Regions of the Larynx of the Rat, Mouse, and Hamster.- Effects of Xenobiotics on the Larynx of the Rat, Mouse and Hamster.- Development of Syrian Golden Hamster Tracheal Epithelium During Prenatal and Immediate Postnatal Stages.- Neoplasms.- Morphological Response of Respiratory Epithelium to Carcinogens, Syrian Hamster (Mesocricetus auratus W.).- Nasal Neoplasia.- Hemangiosarcoma, Nasal Cavity, Mouse.- Neuroendocrine Hyperplasias and Tumors, Larynx and Trachea, Syrian Hamster.- Lesions Due to Infection.- Murine Respiratory Mycoplasmosis, Rat and Mouse.- Rat Coronavirus Infection, Upper Respiratory Tract, Rat.- The Lung (Bronchi, Bronchioles, Alveolar Ducts, Alveoli, Pleura).- Histology, Ultrastruture, Function.- Structure and Function of the Lung.- In Vitro Differentiation of an Epithelial Stem Cell Line Derived from the Fetal Syrian Hamster Lung.- Comparative Aspects of Pulmonary Carcinogenesis.- Alveolar/Bronchiolar Hyperplasia, Adenoma and Carcinoma, Lung, Rat.- Naturally Occurring Pulmonary Tumors in Rodents.- Squamous Cell Carcinoma, Lung, Rat.- Radiation-Induced Squamous Cell Carcinoma, Lung, Rat.- Radiation-Induced Adenocarcinoma, Lung, Rat.- Radiation-Induced Sarcomas, Lung, Rat.- Radiation-Induced Adenosquamous Carcinoma, Lung, Rat.- Pleural Mesothelioma, Syrian Hamster.- Metastatic Tumors, Lung, Mouse.- Nonneoplastic Lesions.- Bleomycin-Induced Injury, Mouse: A Model for Lung Injury.- Fibroblast Interactions with Epithelial Cells in Lung Injury and Repair.- Fibroblast Interactions with Alveolar and Interstitial Macrophages. Models: Silicosis and Asbestosis in the Mouse.- Pulmonary Lipidosis, Rat.- Alveolar Lipoproteinosis, Rat.- Fly Ash Pneumoconiosis, Hamster.- Asbestosis, Hamster.- Squamous Metaplasia, Lung, Rat.- Pulmonary Hair Embolism, Rat.- Goblet Cell Metaplasia, Lung, Rat.- Lesions Due to Infection.- Sendai Virus Infection, Lung, Mouse, and Rat.- Pneumonia Virus of Mice Infection, Lung, Mouse, and Rat.- Rat Coronavirus Infection, Lung, Rat David G. Brownstein.- Cilia-Associated Respiratory Bacillus Infection, Rat, Mouse, and Rabbit.- Pneumocystosis, Lung, Rat.- Toxoplasmosis, Lung, Mouse, and Hamster.- Aspergillosis and Mucormycosis, Lung, Rat.