Reoviruses are one of the most important viral groups for understanding the molecular and genetic basis for viral pathogenesis. These two volumes cover virtually all aspects of reovirus biology. Volume I begins with a review of reovirus structure; further chapters deal with functions of the reovirus structural proteins, the assembly of the genome, and reovirus mutants. Volume II reviews general mechanisms of reovirus persistent infection and cytopathic effects, and then discusses reovirus-induced disease in specific organ systems including the heart, nervous and endocrine systems, liver and biliary system, and intestine. Together, these two volumes provide a current and comprehensive review of the mammalian reoviruses.

Inhalt

List of Contents.- Molecular Mechanisms of Persistent Infection by Reovirus.- Apoptosis and the Cytopathic Effects of Reovirus.- Pathogenesis of Reovirus Myocarditis.- Pathogenesis of Reovirus Gastrointestinal and Hepatobiliary Disease.- Reovirus and Endocrine Cells.- Pathogenesis of Reovirus Infections of the Central Nervous System.- Reovirus and the Interferon System.- Cellular and Humoral Immunity to Reovirus Infection.- Mucosal Immunity to Reovirus Infection.- Subject Index of Companion Volume 233/I.