Regenerative medicine is the emerging science of how we can support our body to repair itself and encompasses innovative strategies to facilitate recovery after organ injury. Several types of blood-derived stem cells can be easily procured and have the potential to facilitate this repair process. Our understanding of the various cell types and precise mechanisms of repair are evolving quickly. In this book, several key types of blood-derived stem cells that participate in the repair of organ damage are reviewed and specific examples of how stem cells may improve heart damage and neurological injury are addressed. Practical approaches to preparing cellular products and regulatory issues that will govern translational studies in patients are also covered. Regenerative Therapy Using Blood-Derived Stem Cells is a timely publication of a fast-moving field that will stimulate further research and enquiry into the promising field of regenerative medicine.

Autorentext

Dr. David S. Allan is a clinician scientist at the Ottawa Hospital Research Institute, affiliated with the Blood & Marrow Transplant Program at the University of Ottawa. His research interests focus of fundamental aspects of vascular progenitor biology and on translational studies in the repair of organ toxicity in patients undergoing hematopoietic stem cell transplantation.

Dr. Dirk Strunk is a clinician scientist with the Hematopoietic Stem Cell Transplantation Program and Head of Stem Cell Research at the Medical University of Graz in Austria. His research team develops novel transplantation strategies using mesenchymal stromal cells and endothelial progenitors and has developed animal protein-free methods of cell expansion that facilitate translational studies in humans.

Zusammenfassung

Blood has long been viewed as a conduit for therapy, stemming from the ancient days of phlebotomy to remove evil humors to the development of successful blood transfusions to replace missing blood components. The identification and characterization of hematopoietic stem cells by Drs. Till and McCulloch revolutionized the field and soon after, non-hematopoietic stem and progenitor cells were characterized from the blood and bone marrow. Some of these cell types and various blood-derived cell lineages are involved in the repair of various types of tissue damage that span the spectrum of medical disorders. The goal of this book is to provide an up-to-date review of the various types of blood-derived cells with regenerative capacity, identify opportunities for intervention by examining specific clinical applications, and recognize the regulatory environment that will encompass future therapies in regenerative medicine.

Inhalt

Undertaking Regenerative Medicine Studies with Blood Stem Cells.- Defining Endothelial Progenitor Cells.- Blood-Derived ALDHhi Cells in Tissue Repair.- Blood Derived Mesenchymal Stem Cells and Tissue Repair.- Animal Protein-Free Expansion of Human Mesenchymal Stem / Progenitor Cells.- Defining Hierarchies of USSC and MSC in Cord Blood.- iPS Cells from Blood-Derived Cells.- Endothelial Progenitors and Repair of Cardiovascular Disease.- Bone Marrow-Derived Cells as Treatment Vehicles in the Central Nervous System.- Regenerative Potential of Blood Stem Cell Products Used in Hematopoietic Stem Cell Transplantation.- Concepts to Facilitate Umbilical Cord Blood Transplantation.- Cord Blood Banking for Regenerative Therapy.- Regulatory Questions in the Development of Blood Stem Cell Products for Regenerative Therapy.- Cell Therapy Regulations from a European Perspective.- EBMT Registry of Non-Hematopoietic Stem Cells and Regenerative Therapy (Cellular and Engineered Tissue Therapies in Europe).