Radiolabeled Cellular Blood Elements

Preparing manuscripts with figures and tables for camera repro­ duction was a formidable task. Care has been taken for consistency and typographic accuracy. However, I make no claim that no errors exist in this volume. ,I hope, however, that the reader will under­ stand and ignore any error and find this compendious volume useful for numerous biologic studies, physiologic explorations and clinical app­ lications of radiolabeled cellular blood elements in years to come. M. L. Thakur Editor, and the ASI Director ACKNOWLEDGEMENTS Dr. Max Hardeman of the University of Amsterdam and Dr. Michael Ezekowitz of Yale University served as the codirectors of the Advanced Study Institute (ASI). Dr. Hardeman spent countless hours and contri­ buted to the scientific program, took care of mailings in Europe, organized transportation in Italy, and communicated with the hotel management on numerous occasions. I cannot thank him enough! Dr. Ezekowitz collected some manuscripts and corrected a few. I am grateful to him. I take this opportunity once again to thank all the guest fac­ ulty, who, despite their busy schedules and time constraints, accepted my invitation and made valuable contributions to the ASI. I am also grateful to all participants, who were so friendly and were primary resources for many lively discussions. They made the ASI profession­ ally beneficial and socially enjoyable.

Inhalt

Pathophysiology, Biochemistry, and Pharmacology of Platelets.- Physiology and Pathophysiology of Human Neutrophils.- Migratory Properties and Radiosensitivity of Lymphocytes.- Cell Isolation Techniques: A Critical Review.- Techniques of Cell Labeling: An Overview.- Evaluation of Animal Models using In-111-Labeled Platelets.- Platelet Kinetics.- In Vivo Quantification and Platelet Survival Studies: What is the Best Approach.- Indium-111 Platelets in Thromboembolism: Can Labeled Platelets be used to Evaluate Antithrombotic Therapy?.- The Use of Indium-111 Platelet Scintigraphy in Man: Comparisons with In Vitro Tests and In Vivo Platelet Function - A Five-Year Experience.- The Use of Indium-111-Labeled Platelets in the Management of Renal Transplant Patients.- Indium-111-Platelets in Bypass Grafts: Experimental and Clinical Applications.- Present Trends and Future Directions in "Leukocyte Labeling".- Granulocyte Kinetics.- Imaging Infection with Indium-111-Labeled Leukocytes.- Lymphocyte Migration Studies in Man.- Indium-111-Labeled Cells: New Approaches and Radiation Dosimetry.- Radiolabeled Red Blood Cells: Status, Problems, and Prospects.