This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models.

Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.

Autorentext
Dr. Luigi PirtoliRadiation Oncology UnitDepartment of Medicine, Surgery and NeurosciencesUniversity of SienaSiena, Italy
Dr. Giovanni Luca GravinaDepartment of Biology and BiotechnologyUniversity of PaviaRome, Italy
Antonio GiordanoSbarro Institute for Cancer Research and Molecular Medicine and Center for BiotechnologyTemple UniversityPhiladelphia, PA, USADepartment of Medicine, Surgery & NeurosciencesUniversity of SienaSiena, Italy

Inhalt
Introduction and Background.- The Radio-resistance of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options.- Radiobiological Hints from Clinical Studies.- Chemo-radiotherapy: Radiation Total Dose and Fractionation.- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy.- Mathematical Modeling of Radiobiological Parameters from Clinical Studies.- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series.- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond.- Basic Knowledge of Glioblastoma Radiobiology.- Molecular Radiobiology and Mathematical Modeling.- Genetic and Epigenetic Determinants in Tumor Initiation and Progression.- Tumor Microenvironment.- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy.- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models.- Glioma Stem-like Cells and Radiation Resistance.- Hypoxia and Radiation Resistance.- Invasiveness and Radiation Failures.- Nanoparticle Technology for Research Radiobiology.- The Molecular Classification of Glioblastoma as a Translational Instrument.- Translational Perspectives for Gene Therapy.- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods.- From Molecular to Clinical Radiation Biology.- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results.- Conclusive Remarks and Perspectives for Future Research.