This book constitutes the post-conference proceedings of the 4th International Conference on Problems of Logistics, Management and Operation in the East-West Transport Corridor, PLMO 2025, held in Baku, Azerbaijan, during May 13-15, 2025. The 12 full papers and 3 short papers included in this book were carefully reviewed and selected from 57 submissions. The papers focus on challenges in transportation of goods across different modes and explore solutions through digital technologies and the digital economy.