The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD.

The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases.

Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.

Autorentext

Dr. Musthafa Mohamed Essa, Ph.D., is an Associate Professor of Nutrition at Sultan Qaboos University, Oman and holding visiting A/Prof position in Neuropharmacology group, ASAM, Macquarie University, Sydney, Australia. He is an Editor-in-Chief for International Journal of Nutrition, Pharmacology, Neurological Diseases published by Wolters & Kluwer, USA. He is also acting as an Associate Editor for BMC complementary and alternative medicine and Editor for Frontiers in Biosciences. Dr. Essa is involved in the editorial / reviewer board of various well known journals such as Frontiers in Neurology, Biochemie, PLOS one, etc. Dr. Essa is conducting research on the effect of dietary supplementation of natural products on Neurodegenerative diseases. He is an expert in the field of Nutritional Neuroscience/ Neuropharmacology and published more than 120 papers, 46 book chapters and 11 books. He has strong international collaborations with institutes in USA, Australia, Qatar, and India. In 2015, Dr. Essa founded a new foundation named Food and Brain Research Foundation to support research in nutritional neuroscience.

Dr. Essa is recipient for so many awards from local and international bodies. In 2017, July his book titled Food and Parkinson's disease was awarded as best book in the world by GOURMAND Cook Book Awards. In 2015, one of his book titled Food and Brain health was awarded as best book in the World by GOURMAND Cook Book Awards and same book was awarded best in the best in the world of past 20 years of awards by GOURMAND Cook Book Awards. In 2015 and 2016, Dr. Essa received the National Research Award under health sector from The Research Council, Oman. In 2013 and 2017, he was awarded as Distinguished Researcher in Sultan Qaboos University, Oman. One of his scientific images won the Best of the Show, Best of overall in all categories and individual as well in the Science of Art- Photo Contest in ISN-ASN International meeting in Mexico, 2013. Further, in 2010, Dr. Essa received the Professional from Developing Country Award from IMFAR, USA. In 2009 and he was awarded ASN Young Investigator Educational Enhancement Award (ASN-YIEE-2009).

He has over 15 years of research and teaching experience and till now he has received many research grants from local and international agencies in the area of Neuropharmacology and nutritional neurosciences (approximately 1.31 million USD). He has guided 3 PhD students and 9 master students. Currently he is guiding 2 PhD students in the area of Nutritional Neuroscience.

Dr. M. Walid Qoronfleh, Ph.D., MBA, is currently the Director of Healthcare Research and Policy at Qatar Foundation-World Innovation Summit for Health (WISH). Dr. Qoronfleh leads the WISH Doha-based research unit which is engaged in research areas that are of immediate global and local healthcare relevance to Qatar. The research is undertaken with a view to positively impacting health policy. These areas include autism, mental health, dementia, patient safety, non-communicable diseases (cancer, diabetes & obesity), precision medicine and bioethics.

Immediately prior to WISH, Walid was the Biotechnology Development Director at Hamad Bin Khalifa University - Qatar Biomedical Research Institute (HBKU-QBRI). Dr. Qoronfleh has over 20 years of scientific, technology, business, and commercial experience. He has held several senior management and executive positions with increasing responsibilities at GlaxoSmithKline (GSK), Sanofi, US National Institutes of HealthNational Cancer Institute (NIH-NCI), ThermoFisher, NextGen Sciences (VP, Personalized Medicine) and SDIX (Executive Director, Diagnostics business, Nasdaq: SDIX) and Executive Director & PI at The University of Michigan Ann Arbor. Dr. Qoronfleh has been awarded two pioneering grants. As a PI at the University of Michigan Ann Arbor he was awarded $3.2M to build a state-wide medical research infrastructure by The Michigan Development Economic Corporation (MEDC). Previously, while at ThermoFisher-Senior Director R&D, as a co-applicant (co-PI/Investigator) he was awarded a 7-year NIH grant with the Medical College of Wisconsin (MCW) to establish a proteomic center ($16.0M).

Dr. Qoronfleh is also involved on different levels in Government-University-Industry partnerships through research, technology and commercialization as well as higher education, research capacity building and grant program management. Dr. Qoronfleh brings expertise in economic development and business improvement in knowledge-based economy (Leadership, Entrepreneurship & Innovation) where he also lectures locally and at HEC Paris in Qatar. Dr. Qoronfleh was an active member of the Arab Expatriate Scientists group in Qatar. He is also one of the ma...

Inhalt
Section I

Autism Spectrum Disorder from Background to Interplay of Genetic, Epigenetic, Environmental Risk Factors and Nutraceuticals

Section I Overview and Reflection

M. Walid Qoronfleh*,  Nader Al-Dewik and Musthafa Mohamed Essa

Overview and Introduction to Autism Spectrum Disorder (ASD)

Nader Al-Dewik*, Rana Al-Jurf, Meghan Styles, Mohammad Badawi, Dalal Alsharshani, Mohammed Alsharshani, Azhar Khattab, Amal I Ahmad, Hilal Al Rifaia, and M Walid Qoronfleh

New Horizons for Molecular Genetics Diagnostic and Research in Autism Spectrum Disorder

Nader Al-Dewik* and Mohammed Alsharshani

Genomics of Autism

Khalid A. Fakhro*

Neuropsychopathology of Autism Spectrum Disorder: complex interplay of genetic, epigenetic and environmental factors

Ranjana Bhandari, Jyoti K Paliwal, and Anurag Kuhad*

Maternal Prenatal Exposures in Pregnancy and Autism Spectrum Disorder- an insight into the epigenetics of drugs and diet as key environmental influences

Kholoud N. Bastaki, Sura Alwan, and Farah R. Zahir*

Psychological Comorbidities in Autism Spectrum Disorder

Eman Shaltout, Nader Al-Dewik, Muthanna Samara*, Hisham Morsi, and Azhar Khattab

Role of Oxidative Stress and Antioxidants in Autism

Thamilarasan Manivasagam, Selvaraj Arunadevi, Mustafa Mohamed Essa, Chidambaram Saravana Babu, Anupom Borah, Arokiasamy Justin Thenmozhi1*, and M Walid Qoronfleh

The Regulation of Reactive Neuroblastosis, Neuroplasticity and Nutraceuticals for Effective Management of Autism Spectrum Disorder GP Poornimai Abirami, Risna Kanjirasseri Radhakrishnan, Esther Johnson, Syed Aasish Roshan, Ajisha Yesudhas, Suhadha Parveen, Abir Biswas, Vijaya Roobini Ravichandran, Anusuyadevi Jayachandran*, and Mahesh Kandasamy*

** **

Section II

Specific Foods and Nutrient Qualities in Autism

Section II Overview and Reflection

M.…