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The study of epigenetics, or how heritable changes in gene
expression are regulated without modifying the coding DNA sequence,
has become an increasingly important field of study in recent
years. Rapid developments in our understanding of the way in which
gene function is modulated by the environment has revolutionized
the way we think about human development and health. Nutrition
in Epigenetics reviews the latest research looking at the
interaction between genes and nutrients and the role they play
together in maintaining human health.
Nutrition in Epigenetics is divided into two primary
parts. The first part provides key principles such as epigenetic
mechanisms, developmental epigenetics, and the role of epigenetics
in disease. The second part looks specifically at the application
of epigenetics to the field of human nutrition. Chapters review the
role of specific nutrients in modulating epigenetic status and the
effect on health and disease.
Nutrition in Epigenetics is an indispensable resource for
researchers, professionals and advanced students with an interest
in human nutrition, epigenetics, and biomedical research.
Autorentext
Mihai D. Niculescu is an Assistant Professor of Nutrition at
the University of North Carolina's Gillings School of Global
Public Health in Chapel Hill, and at the UNC Nutrition Research
Institute in Kannapolis, North Carolina, USA.
Paul Haggarty is Head of the Lifelong Health Programme,
and the Nutrition and Epigenetics Group, at the Rowett Institute of
Nutrition and Health in the University of Aberdeen in Aberdeen,
Scotland.
Zusammenfassung
The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health.
Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease.
Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.
Inhalt
Contributors vii
Part I: Fundamental Principles in Epigenetics
**Section A: Epigenetic Mechanisms
DNA Methylation 13
Natalia V. Cucu
Chromatin Modifications 47
Sandra B. Hake
Roles of RNAi and Other Micro-RNAs in the Regulation of Epigenetic Processes 73
Muller Fabbri
Epigenetic Inheritance: Both Mitotic and Meiotic 87
Nina J. Kaminen-Ahola, Arttu I. Ahola, and Emma Whitelaw
Section B: Development Epigenetics
Section C: Epigenetic Mechanisms in Disease
Epigenetics, Nutrition, and Cancer 129
Amy R. Johnson
Metabolic Syndrome, Obesity, and Diabetes 145
Karen D. Corbin
Autoimmunity 165
Donna Ray and Raymond Yung
Cardiovascular Diseases 173
Aurelian Bidulescu and Methode Bacanamwo
Part II: Nutritional Status and Specific Nutrients
Section A: Maternal Nutrition and Fetal Development
Section B: Role of Specific Nutrients
Folate, Vitamin B12, and Vitamin B6 211
Patrick J. Stover
Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing Brain Development 225
Steven H. Zeisel
Epigenetic Regulation by Retinoids 241
Amandio Vieira
We Are What We Eat: How Nutritional Compounds Such As Isoflavones Shape Our Epigenome 249
Carlos M. Guerrero-Bosagna and Susan J. Clark
Isothiocyanates and Polyphenols 263
Nigel J. Belshaw and Ian T. Johnson
Section C: Macronutrient Intakes
Section D: Environmental Exposures
Section E: Epidemiology of Nutritional Epigenetics
Epigenetics, Nutrition, and Reproduction: Short- and Long-Term Consequences 311
Paul Haggarty
Nutrition, Epigenetics, and Cancer: An Epidemiological Perspective 329
Audrey Jung and Ellen Kampman
Index 345