Nuclear Magnetic Resonance Spectroscopy in Molecular Biology

Proceedings of the 11th Jerusalem Symposium on Quantum Chemistry and Biochemistry held in Jerusalem, Israel, April 3-7, 1978

Inhalt

P-31 NMR of nucleic acids. Bond angle and torsional effects.- NMR studies on dynamic properties of nucleic acid base pairs in nonaqueous solvents.- NMR studies and minimum energy conformation calculations on the 5?-terminus of mammalian mRNA.- Solution conformations of purine (?) nucleosides and analogs.- Nitrogen-15 nuclear magnetic resonance spectroscopy of 15N-labeled nucleotides. Investigations of Ribonuclease A - Nucleotide interactions.- Co-operative conformational properties of nucleosides, nucleotides and nucleotidyl units in solution.- The quantitative separation of stacking and self-association phenomena in a dinucleoside monophosphate by means of NMR concentration-temperature profiles: 6-N-(dimethyl) adenylyl-(3?, 5?)-uridine.- The contributions of the purine nitrogens to stacking association.- Methylation effects on nucleic acid conformations.- Structural studies on the yeast tRNAPhe by the 1H NMR of modified bases. Effect of removal of the Y base and anticodon binding.- Spectroscopic Studies of drug-nucleic acid interactions.- A model for the specific site melting of DNA in vivo.- On the conformational dependence of the proton chemical shifts in nucleosides and nucleotides. IV. Proton chemical shifts in 3?-nucleotides as a function of different conformational parameters.- Some comments and comparisons concerning the use of 'ring-current' calculations in elucidating molecular conformations.- Carbon-13 NMR results in the field of nitrogen heterocycles: the detection of protonation sites.- NMR studies of the molecular dynamics of peptides and proteins.- Structural information from photo-CIDNP in proteins.- Nitrogen 15 nuclear magnetic resonance investigations on amino acids.- One-bond C, H coupling constants, a new parameter in conformational studies of peptides? The cyclo-sarcosyls.- NMR saturation transfer studies of the catalysis of the reversible hydration of acetaldehyde by carbonic anhydrase.- Conformation and interaction with small molecules of cyclic hexapeptides as studied by nuclear magnetic resonance spectroscopy and circular dichroism.- 13NMR studies on OPIOID peptides; 13C-enriched methionine-enkephalin and ?-endorphin.- NMR studies of selectively deuteriated and fluorine labelled dihydrofolate reductase.- Studies of 19F labeled met-192 chymotrypsin: an NMR study of an activating moiety near the catalytic serine.- Principles in substrate and conformation specificity of nucleotide-converting enzymes.- Cooperativity in the binding of ligands to dihydrofolate reductase.- Studies of gene-5 protein nucleic acid interaction.- Structural elucidation studies of aurintricarboxylic acid, a potent inhibitor of protein nucleic acid interactions.- Magic angle sample spinning in inhomogeneously broadened spin systems - application to unsonicated phospholipid bilayers.- Ionic permeabilities of membranes; NMR kinetic studies.- Interaction of cannabinoids with model membranes - NMR studies.- NMR spectra of mucopolysaccharides.- An in vivo15N NMR study of bacterial cell walls.- The application of aromatic ring currents in the elucidation of drug-ligand and metallo-porphyrin complexations.- Sodium magnetic resonance in biological systems. Interpretation of the relaxation curves.- NMR spectroscopy of tricyclic non-alternant systems containing seven-membered rings, dibenz [b, f] oxepine and dibenz [b, f] azepine: parents of pharmacologically active systems.- Appendix: Discussion document on nomenclature.- Index of Subjects.- Index of Names.