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Ultrastructural Pathology, Second Edition is a comprehensive reference on electron microscopy of pathologic tissue in animals and humans. Now presented in an atlas format for easier identification of organelles, the text is designed to bridge the gap between what is seen in the electron microscope at the cellular level and what the pathologist encounters in the postmortem room. New to this edition are sections on diagnostic electron microscopy, providing information on specialized technologies for electron microscopy, and invertebrate pathology. Emphasizing comparative pathology, the book explains and integrates all aspects of cellular changes in lesions occurring from natural or experimental disease.
Autorentext
Norman F. Cheville, DVM, PhD, is Professor Emeritus of Veterinary Pathology at Iowa State University. Previously, he was Chair of the Department of Veterinary Pathology and Dean of the College of Veterinary Medicine at Iowa State University, and was Chief of Pathology at the National Animal Disease Center in Ames, Iowa.
Zusammenfassung
Ultrastructural Pathology
Inhalt
Preface xi
Contributors xiii
Prologue xv
Part I: Structural Basis of Cell Injury 3
1 Response to Cellular Injury 5
Acute Cell Swelling 5
Adaptive Responses to Persistent Injury 21
2 Cell Death 33
Necrosis 35
Programmed Cell Death 40
Interplay of Necrosis and PCD 49
Getting Rid of the Dead Cell 52
Endothelial Cell Death 54
3 Cellular Defense and Recovery 61
Plasma Membrane in Recovery 61
Detoxification: Smooth Endoplasmic Reticulum and Peroxisomes 62
Mitochondria in Recovery 63
Nucleoli, DNA, and the Genome in Recovery 64
Proteostasis 67
Autophagy: Removal of Debris 69
Part II: Organelle Pathology 75
4 The Cell Surface 77
The Plasma Membrane 77
Cytoskeleton 86
Intercellular Junctions 97
Surface Structures 101
5 Intracellular Trafficking 109
Endocytosis 109
Phagocytosis 115
Lysosomes and Cytoplasmic Trafficking 116
Exocytosis 118
6 Nucleus, Ribosomes, the Golgi Complex, and Secretion 125
Nucleus 125
Ribosomes 136
Rough Endoplasmic Reticulum 138
Golgi Complex 139
Secretion 142
7 Peroxisomes, Smooth Endoplasmic Reticulum, and Lipids 153
Peroxisomes 153
Smooth Endoplasmic Reticulum 156
Glycogen 161
Lipids 164
Lipoproteins 169
Lipid Metabolism Disorders 173
8 Mitochondria 181
The Normal Mitochondrion 181
Mitochondrial Swelling: Response to Acute Injury 184
Mitochondriopathy of Metabolic and Chronic Diseases 188
Mitochondrial DNA-Based Disorders 193
Part III: Inflammation and Hemostasis 199
9 Endothelium 201
Endothelial Interface with Blood and Perivascular Space 201
Endothelial Thromboresistance vs. Procoagulation 206
Endothelial Response to Hypoxia and Circulatory Dysfunction 208
Inflammation 209
Mast Cell and Basophil Interface with Endothelium 217
Angiogenesis 223
10 Leukocytes and Platelets 231
The Neutrophil 231
Eosinophils 243
Platelets 246
Thrombosis 257
11 The Mononuclear Phagocyte System and Lymphocytes 269
The Monocyte-Macrophage System 269
Dendritic Cells 274
Lymphocytes 283
12 The Extracellular Matrix 295
Collagen Fibers 297
Microfibrils 303
Extracellular Ground Substance 304
Basement Membranes 307
Mucins and Other Barriers 310
Part IV: Infectious Diseases 317
13 Cytopathology of Viral Diseases 319
Family Poxviridae 319
Family Herpesviridae 327
Family Adenoviridae 338
Family Papillomaviridae 343
Family Polyomaviridae 347
Family Parvoviridae 349
Family Iridoviridae 353
Family Asfarviridae 353
Family Hepadnaviridae 354
Family Circoviridae 355
Family Orthomyxoviridae 356
Family Paramyxoviridae 358
Family Rhabdoviridae 366
Family Filoviridae 369
Family Coronaviridae 370
Family Reoviridae 373
Family Arenaviridae 379
Family Togaviridae 381
Family Arteriviridae 384
Family Bornaviridae 386
Family Flaviviridae 386
Family Bunyaviridae 391
Family Birnaviridae 392
Family Nadoviridae 394
Family Picornaviridae 394
Family Caliciviridae 399
Family Astroviridae 401
Family Retroviridae 401
14 Cytopathology of Pathogenic Prokaryotes 425
Structure of the Bacterial Cell 425 Phylum Tenericutes, Ord...