In this timely and up-to-date book, the latest knowledge on neurological syndromes due to neurotoxicity of antineoplastic drugs is presented. The initial chapters discuss the following vital topics: - the importance of blood-brain barrier changes in cancer patients, - laboratory and clinical studies on the neurotoxicity of anticancer drugs, - and the role of cumulative toxicity of radiation therapy and chemotherapy. Clinical presentation and diagnosis of various neurological conditions related to antineoplastic chemotherapy are then also thoroughly discussed. Indispensable to the neuro-oncologist and useful to all physicians managing cancer patients, this book is a valuable source of current information.

Inhalt

Introduction: Purposes and Plan.- The Blood-Brain Barrier: Morphology, Physiology and its Changes in Cancer Patients.- Mechanisms of Neurotoxicity and Experimental Models.- Neurotoxicity of Combined Radiation and Chemotherapy.- Acute Encephalopathy and Seizures.- Chronic Encephalopathies.- Cerebellar Disorders.- Acute Meningeal Reaction.- Acute Meningospinal Syndromes: Acute Myelopathy and Radiculopathy.- Peripheral Neuropathy.