The field of neuroinflammation is evolving rapidly and now yielding many new potential therapeutics for clinical trials. In this thoroughly updated and revised edition of his much praised book, Neuroinflammation: Mechanisms and Management, Second Edition, Paul L. Wood and a panel of leading researchers capture all these new developments in a masterful synthesis of what is known today about the inflammatory mediators and the cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.
Up-to-date and insightful, Neuroinflammation: Mechanisms and Management, Second Edition summarizes all the recent discoveries now playing a key role in both developing molecular targets and designing a new generation of drugs for acute and chronic neurodegenerative disorders alike.

Klappentext

In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

Inhalt

I. Neuroinflammatory Mechanisms Microglia: Roles of Microglia in Chronic Neurodegenerative Diseases Paul L. Wood Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration Kurt A. Jellinger Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration Christopher C. J. Miller, Steven Ackerley, Janet Brownlees, Andrew J. Grierson, and Paul Thornhill Roles of Chemokines and Their Receptors in Neuroinflammation Andrzej R. Glabinski and Richard M. Ransohoff Neurotoxic Mechanisms of Nitric Oxide Kathleen M. K. Boje Chronic Intracerebral LPS as a Model of Neuroinflammation Gary L. Wenk and Beatrice Hauss-Wegrzyniak Peroxisome Proliferator-Activated Receptor Gamma Agonists: Potential Therapeutic Agents for Neuroinflammation Gary E. Landreth, Sophia Sundararajan, and Michael T. Heneka Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitrones as Therapeutics Robert A. Floyd and Kenneth Hensley II. Stroke and TBI Inflammation and Potential Anti-Inflammatory Approaches in Stroke Jari Koistinaho and Juha Yrjänheikki Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury Yuji Taoka and Kenji Okajima Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia Yvan Gasche, Jean-Christophe Copin, and Pak H. Chan III. Alzheimer's Disease Neuroinflammatory Environments Promote Amyloid-b Deposition and Posttranslational Modification Craig S. Atwood, Mark A. Smith, Ralph N. Martins, Rudolph E. Tanzi, Alex E. Roher, Ashley I. Bush, and George Perry Microglial Responses in Alzheimer's Disease: Recent Studies in Transgenic Mice and Alzheimer's Disease Brains Douglas G. Walker and Lih-Fen Lue The Amyloid Hypothesis of Cognitive Dysfunction Dave Morgan and MarciaN. Gordon The Cerebellum in AD: A Case for Arrested Neuroinflammation? Paul L. Wood The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration G. Jean Harry and Christian Lefebvre d'Hellencourt Inflammation and Cyclo-Oxygenase in Alzheimer's Disease: Experimental Approaches and Therapeutic Implications Patrick Pompl, Tara Brennan, Lap Ho, and Giulio Maria Pasinetti IV. Multiple Sclerosis Experimental Autoimmune Encephalomyelitis Hans-Peter Hartung and Bernd C. Kieseier Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosis Claudia F. Lucchinetti, W. Brück, and Hans Lassmann In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases Annachiara Cagnin, Alexander Gerhard, and Richard B. Banati V. Parkinson's and Huntington's Diseases Inflammatory Mechanisms in Parkinson's Disease Joseph Rogers and Carl J. Kovelowski Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegeneration Hideki Hida, Hiroko Baba, and Hitoo Nishino Index