This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others.

Written by world-renowned scientists in the field, Neural Stem Cells in Development, Adulthood and Disease presents cutting-edge studies of interest to both established neurogenesis researchers and readers with general interests in nervous system science. It is an authoritative addition to the Stem Cell Biology and Regenerative Medicine series.

Autorentext

H. Georg Kuhn, PhD, is a professor of regenerative neurosciences at the Institute for Neuroscience and Physiology at the University of Gothenburg in Sweden. He is the scientific coordinator for the Center for Brain Repair and Rehabilitation and for the Area for Mind, Brain, Learning and Environment (AMBLE) at the University of Gothenburg. Dr. Kuhn received his PhD from the University of Düsseldorf in Germany and conducted his postdoctoral training in cellular neuroscience and stem cell biology at the University of California San Diego and the Salk Institute in La Jolla, California. Dr. Kuhn's research interests are in neural stem cells of the adult brain as well as neuroregenerative and neuroplasticity mechanisms.

Amelia J. Eisch, PhD, is a tenured associate professor of psychiatry at the University of Texas Southwestern Medical Center (UTSW) in Dallas, Texas. Dr. Eisch earned her PhD in psychobiology from the University of California Irvine with John F. Marshall, PhD, and was a postdoctoral fellow at Yale University School of Medicine with Eric J. Nestler, MD, PhD, when she first discovered the relationship between new neurons in the adult brain and animal models of psychiatric disorders, like addiction and depression. In her basic neuroscience laboratory at UTSW, Dr. Eisch and her group work to understand how molecular and cellular changes influence both normal behavior and cognitive functioning. She is particularly interested in understanding how adult neurogenesis can also contribute to abnormal functioning that has relevance to neuropsychiatric disorders like addiction and depression.

Inhalt
1.Adult neurogenesis and regeneration: focus on non-mammalian vertebrates.- 2.Differential intrinsic and extrinsic regulations of the two adult neurogenic regions.- 3.The role of adult-born dentate granule neurons in the regulation of mood.- 4.Stem cells and neurogenesis in relation to dementia and Alzheimer's disease mouse models.- 5.Hippocampal neurogenesis in neurodegenerative movement disorders.- 6.Linking Adult Neurogenesis To Epilepsy Through Epigenetics.- 7.Activity-based maintenance of adult hippocampal neurogenesis: maintaining a potential for lifelong plasticity.- 8.Neural stem cells and demyelinating disease.- 9.Stem Cell-Based Therapies For Spinal Cord Regeneration.- 10.Direct reprogramming of somatic cells into induced neuronal cells: where we are and where we want to go.