Nephrotoxicity in the experimental and clinical situation

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Inhalt

1. Fixation of renal tissue for cytochemical evaluation.- 2. The application of histochemistry at the light microscopic level to the study of nephrotoxicity.- 3. Cryomicrotomy of renal tissue, and the use of X-ray microanalysis and autoradiography at the light and electron microscopic levels.- 4. Fixation of kidney tissue for morphometric study.- 5. Correlating structural and functional changes in nephrotoxic renal injury.- 6. Naturally occurring renal disease in non-human primates.- 7. Chemically induced epithelial tumours and carcinogenesis of the renal parenchyma.- 8. Assessment of the kidney in relation to blood pressure regulation.- 9. Renal slices and perfusion.- 10. The use of single nephron techniques in renal toxicity studies.- 11. Prostaglandins and other eicosanoids.- 12. Xenobiotic metabolism in the mammalian kidney.- 13. Metabolism of glutathione in the kidney.- 14. Metabolic activation of halogenated chemicals and its relevance to nephrotoxicity.