The third edition of this important, gold-standard title outlines a range of significant advances in the study and understanding of myasthenia gravis. The overarching goal of this new edition is identical to the first and second -- to provide the clinician and the scientist with a common resource for understanding the profound achievements in the clinical, translational, and basic sciences of neuromuscular transmission disorders. In addition to several new authors and an extensive update of all chapters, this third edition includes summaries of pre-clinical research standards for autoimmune MG, along with a broad summary of MG clinical trial performance. The now greater understanding of the clinical presentation of MuSK-related MG and identification of potential new autoantigens, including LRP-4, is discussed. The development of treatment guidelines by groups in Japan, the United Kingdom, Germany, and an international consortium is also outlined. Myasthenia Gravis and Related Disorders, Third Edition, is an invaluable resource for meeting the many and varied needs of clinicians who treat patients with myasthenia gravis.

Autorentext

Henry J. Kaminski, MD

Meta A. Neumann Professor and Chair of Neurology

The George Washington University

Department of Neurology

Washington, DC, USA

Linda L. Kusner, PhD

Associate Professor

The George Washington University

Department of Pharmacology and Physiology

Washington, DC, USA

Inhalt

Chapter 1. Neuromuscular Junction Physiology and Pathophysiology

Chapter 2. Acetylcholine Receptor Structure

Chapter 3. Immunopathogenesis of Myasthenia Gravis

Chapter 4. Animal Models of Myasthenia Gravis for Preclinical Evaluation

Chapter 5. Epidemiology and Genetics of Myasthenia Gravis

Chapter 6. Clinical Presentations of Myasthenia Gravis

Chapter 7. Ocular Myasthenia

Chapter 8. Thymoma-associated Myasthenia Gravis

Chapter 9. Electrodiagnosis of Neuromuscular Junction Disorders

Chapter 10. Autoantibody Testing in the Diagnosis and Management of Autoimmune Disorders of Neuromuscular Transmission and Related Diseases Chapter 11. Treatment of Myasthenia Gravis

Chapter 12. Neurocritical Care of Myasthenic Crisis

Chapter 13. Thymectomy for Non-thymomatous Myasthenia Gravis

Chapter 14. Lambert-Eaton Syndrome

Chapter 15 Acquired Neuromyotonia

Chapter 16. Congenital Myasthenic Syndromes

Chapter 17. Toxic Neuromuscular Transmission Disorders

Chapter 18. Predictors of Psychological Health in Myasthenia Gravis

Chapter 19. Myasthenia Gravis: Classification and Outcome Measurements

Chapter 20. Emerging Therapeutics for Myasthenia Gravis

Chapter 21. Clinical Trial Design for Myasthenia Gravis