Molecular Basis of Thyroid Cancer

Thyroid cancer shows the fastest rate of increase in women in the USA. There is an urgent need to better understand its underlying causes, explore efficient and sensitive methods for its diagnosis, new methods of treatment and follow-up, based on the recent advances in technology.

Molecular Basis of thyroid Cancer brings together top-flight experts from across the globe to consider present state of the art treatment and techniques and what the future holds. The product of this effort is invaluable to endocrinologists, particularly those with an interest in the thyroid, molecular oncologists, nuclear medicine physicians and those in biotechnology intent on devising innovative therapies for cancer.

"Significant advances in our understanding of thyroid cancer have occurred over the previous decade. This text discusses the molecular alterations and pathologic manifestations seen in this disease. Distinguished investigators address both the basic biology and clinical issues pertinent to our understanding and management of patients with thyroid cancer."

Steven T. Rosen, M.D.

Series Editor

Zusammenfassung
Thyroid cancer is the fastest growing cancer in the U.S., especially among women. Given the relative success we have had in its treatment, there is a need to capitalize on it by better understanding the factors that underpin this malignancy, and exploring better strategies for diagnosis, treatment, and follow-up. To do so, we must take full advantage of the revolution in modern biology. This comprehensive volume addresses the needs of a broad readership. Against a backdrop of the complexity of the origins of cancer, pathology of thyroid tumors, including lymphomas, is discussed, as are molecular genetic lesions associated with spontaneous and radiation-related thyroid tumors, diagnostic tests available to surmise tumor subtypes (including a review of the potential of DNA micro arrays), advances in therapeutics (including recombinant hTSH superagonists, allowing for better treatment of well differentiated thyroid carcinoma and its imaging), and combinations of drugs that might influence the course of poorly differentiated and anaplastic thyroid cancer. In this book, we glimpse into the promise of gene therapy in the future management of otherwise lethal anaplastic and poorly differentiated thyroid tumors. The molecular genetics of medullary thyroid cancer is considered in depth, and malignancy is used as a showcase for genetic prediction and counseling.

Inhalt

The Origin of Cancer.- The Pathology of Thyroid Cancer.- Thyroid Lymphomas.- Molecular Events in Follicular Thyroid Tumors.- Molecular Epidemiology of Thyroid Cancer.- Growth Factors and their Receptors in the Genesis and Treatment of Thyroid Cancer.- Biology of Ras in Thyroid Cells.- P53 and other Cell Cycle Regulators.- Abnormalities of Nuclear Receptors in Thyroid Cancer.- Matrix Metalloproteinases in Thyroid Cancer.- The Molecular Pathways Induced by Radiation and Leading to Thyroid Carcinogenesis.- TRK Oncogenes in Papillary Thyroid Carcinoma.- Thyroidal Iodide Transport and Thyroid Cancer.- Molecular Signaling in Thyroid Cancer.- Gene Expression in Thyroid Tumors.- Animal Models of Thyroid Carcinogenesis.- Diagnostic Molecular Markers in Thyroid Cancer.- Thyroid Cancer Imaging.- Past, Presence and Future of Thyroid-Stimulating Hormone (TSH) Superactive Analogs.- Pathobiology of Antineoplastic Therapy in Undifferentiated Thyroid Cancer.- Gene Therapy for Thyroid Cancer.- Familial Papillary Thyroid Carcinoma.- Ret Activation in Medullary Carcinomas.- From Genes to Decisions.