Metastasis

The Metastasis Group of the European Organization for Research on Treatment of Cancer (EORTC) held an International Meeting at the Royal Institution in London on April 2lst-23rd, 1980. The subject was "Clinical and Experimental Aspects of Metastasis" and these Proceedings are the record of that Meeting. Almost all of those who presented a paper or a poster have written up their contributions as chapters of the Proceedings and we have made no distinction here between posters and oral communications. The Organizers and Editors owe a considerable debt of gratitude to all the contributors who without exception presented the results of their work in a clear and concise manner that did much to reveal the essence of the complex problems central to current thinking on met­ astasis. Moreover most manuscripts arrived well within the deadline - a circumstance which in our experience is unusual. Of the large audience who attended the Meeting many had come from the far distant corners of the World and to them as well as to the presenters of papers the Organizers wish to express their deep appreciation.

Inhalt

The Significance of Metastases to the Surgeon.- The Spread of Rectal Cancer into Veins and the Mechanism of Distant Embolism.- Squamous Carcinomas of the Head & Neck: Patterns and Mechanisms of Local Invasion and Metastasis.- The Relationship between Malignant Melanoma Morphology, Metastases and Patient Survival.- Animal Tumour Models: The Intrusion of Artefacts.- Models of Prostate, Breast, Lung and Intestinal Carcinomas which Metastasize in Rats.- A New In-Vitro Model to Study Tumour Cell Invasion.- Invasiveness and the "Metastatic Potential" of Tumour Cells.- A Possibility of Predicting the Metastatic Potential of Tumours by Implantation into Chick Embryo Blastoderms.- An Experimental Study on the Barrier Function of Lymph Nodes to Tumor Cells.- Metastases from DMBA-Induced Carcinomas in Hamster Cheek Pouch.- Quantitation and Cellular Growth of Occult Metastases of a Rat Mammary Carcinoma.- Comparison of Natural and Artificial Lung Metastases from a Murine Tumour of Spontaneous Origin.- Growth Inhibition of Simulated Metastases by a Large Primary Tumor.- Quantitative Studies on Metastasis using Yoshida Rat Ascites Hepatomas, with Special Reference to the Biological Characteristics in Metastasizability and Drug Sensitivity.- Canine Osteosarcoma and Canine Mammary Carcinoma.- Selection of a Human Malignant Melanoma X Hamster Hybrid Cell Line by Metastasis.- Morphological Aspects of the Interaction of Blood Coagulation and Tumour Dissemination.- Cancer Cell Procoagulant Activity, Warfarin and Experimental Metastases.- Molecular Mechanism of Fibrinolysis and its Potential Role in Metastasis.- Fibrinolysis and Anticoagulation in Colo-Rectal Cancer - The Way Ahead.- Studies on Factors Influencing the Lodgement of Circulating Tumour Cells.- Critical Analysis of Experimental Models for the Antimetastatic Effects of Anticoagulants.- Effect of Fibrinolysis Inhibition on the Growth and Hematogenous Dissemination of Cancer.- Mechanisms Behind the Inhibiting Effect of Tranexamic Acid on Tumour Growth and Spread.- The Inhibitory Effect of Sulfated Polysaccharides, Ancrod or Tranexamic Acid on Pulmonary Metastases in Animals.- Prostacyclin as a Marker for Diagnosing and Staging Carcinoma of the Prostate.- Prostaglandins and Metastasis.- The Application of a Defibrinogenating Snake Venom Enzyme in Experimental Tumor Metastasis.- Effect of Ticlopidine on Blood-Borne Metastasis.- Failure of RA233 to Affect the Growth of Intravenously Injected Murine Lymphoma Cells.- Failure of Flurbiprofen to Affect the Metastasis of Rodent Sarcomas.- In Vivo and In Vitro Selection of Experimental Metastatic Variants of Rodent Melanoma, Mammary Carcinoma and Lymphosarcoma.- The Role of Tumor Cell-Basement Membrane Interactions in the Metastatic Process.- Morphological and Biochemical Differences of Primary and Metastatic Human Melanoma Cells.- Lewis Lung Carcinoma: Selecting Metastatic Variants.- Malignant Properties of Clones Isolated from a Mouse Fibrosarcoma.- Characteristics of Tumor Cell Clones with Varying Malignant Potential.- Invasion of Lung and Liver Tissue by Different Types of Tumour Cells.- Interactions of Tumor Cells with Isolated Hepatocytes. A Model for the Infiltration of Blood-Borne Tumor Cells in the Liver.- Ultrastructural Features of Intravascular and Extravascular Migration of Cancer Cells.- Characteristics of Metastasizing and Non-Metastasizing Tumors and their Interaction with the Host Immune System in the Development of Metastasis.- Metastatic Potential of Tumor Cells from Spontaneous Metastasis.- Cell Surface Changes Associated with the Selection of Spontaneous Metastases.- Intrinsic and Extrinsic Factors Governing the Expression of Metastatic Potential.- Metastatic Potential of SK-Br-3 Cells Treated with L-Cysteine or Ascorbic Acid.- Effect of Pre-Treatment with Antisera Against Choriogonadotropin on the Metastatic Potential of a Rat Adenocarcinoma.- Metastases of Mammary Tumours in BR6 Mice.- Fixation of ?-Melanocyte Stimulating Hormone (?-MSH) to Human Metastatic Melanoma Cells In Vitro and In Vivo.- Metastases of Human Tumours in the Nude Mouse: The Behaviour of Colon Carcinoma Xenografts.- Immune Regression of Metastases Following Hyperthermic Treatment of Primary Tumours.- Clonal Tumor Cell Variants Arising by Adaptation.- Reversibility of Immunological and Antitumoral Effects Produced In Vivo by Particulate ?l-3 Glucans.- Modulation of Tumor Growth and Metastasis by an Acute Inflammation.- Enhancement of Pulmonary Metastases Induced in Mice by Cyclophosphamide: Role of the Immune System.- Antimetastatic Effects of Intrapleurally Injected Corynebacterium Parvum.- Does C. Parvum Treatment Affect Tumour Blood Flow and Hence Metastasis?.- Reticuloendothelial System Function in Cancer Patients Treated with C. Parvum.- Inhibition of Pulmonary Metastasis of Lewis Lung Tumor by Nocardia Rubra-Cell Wall Skeleton or Schizophyllan.- Minimal Residual Disease may be Treated by Chessboard Vaccination with Vibrio Cholerae Neuraminidase (VCN) and Tumor Cells.- Application of the Leukocyte Migration Test (LMT) To Patients with Metastases: Evidence in Favour of a Change in Host Response?.- Computed Tomography in the Staging of Malignancy.- Serial Quantitative Skeletal Scintigraphy in Breast Cancer.- Further Studies on the Effect of Prostaglandin Synthesis Inhibitors and Diphosphonates on Tumour-Mediated Osteolysis.- Potential Clinical Use of Diphosphonates against Bone Metastases and Hypercalcaemia of Malignancy.- Multiparametric Biochemical Study in the Diagnosis of Bone Metastasis of Breast Cancer.- Acute Changes in Calcitonin Levels in Lung Cancer Patients Treated with C. Parvum: Do these Reflect In Vivo Killing of Tumour Cells?.- Serial Quantitative Bone Scanning of Metastatic Tumour in Rats.- Experimental Study on Characteristics of Microcirculation in Tumor Tissue, with Reference to Cancer Chemotherapy.- Development of Severe Radiation Pheumonitis in Patients with Oat Cell Carcinoma during Combined Modality Therapy.- Effect of Hemithorax Irradiation of Young Mice on Pulmonary Metastatic Deposits from Subsequently Developing Spontaneous Mammary Tumours.- The Chemotherapy of Micrometastases - An Overview of Current Status.- Adjuvant Razoxane in Resectable Colorectal Cancer.- Changing Aspects in the Surgical Approach to Metastatic Disease; Influence of Chemotherapy on Indications For and Results Of Metastasectomies.- Clinical Study on Selective Enhancement of Drug Delivery by Angiotensin II in Cancer Chemotherapy.- Differences and Similarities in Adjuvant Chemo-Therapy in Mouse and Man.- Drug Response of Two Different In Vitro Tumour Lines Derived from Lung Metastases of 3LL.- Therapeutic Implications of Heterogeneous Tumor Cell Populations.- Effect of Bleomycin Scheduling on Lung Metastases of 3LL and a Subline of Different Metastatic Potential.- Metastas…