Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.

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Preface. I: Subcellular Basis of Heart Failure. 1. Tumor Necrosis Factor Alpha in Chronic Heart Failure; T. Bachetti, et al. 2. Myocardial Ribonuclease Activity in Heart Failure; P. J. O'Brien, et al. 3. Beta-Adrenergic Receptor Mechanisms in Heart Failure; R. Sethi, et al. 4.Vascular alpha-Adrenergic Function in Congestive Heart Failure; Q.P. Feng, J.M.O. Arnold. 5. Altered Myocardial Neurotransmitter and 1,2-Diacylglycerol Concentrations in Right Ventricular Hypertrophy and Failure in Rats; K. Okumura, et al. 6. Metabolic Changes in Non-Ischemic Myocardium During Pump Failure; H. Ishioka, et al. 7. The Cardiac Extracellular Matrix and Its Role in the Development of Heart Failure; H. Ju, I.M.C. Dixon. 8. The SHHF/Mcc-facp Rat Model: A Genetic Model of Congestive Heart Failure; S.A. McCune, et al. 9. Left Ventricular Mass and Diastolic Function in Young Individuals with a First Elevated `Casual' Blood Pressure; S.M. De Lena, et al. 10. Factors Responsible for Left Ventricular Underfilling in Pure Mitral Stenosis; A. Surdacki, et al. 11. Improved Preservation of Myocardial Ultrastructure in Perfusion-Fixed Human Heart Explants; A.M. Gerdes, et al. 12. Involvement of Leukotoxin in Pathogenesis of Patients with Extensive Burns; K. Kosaka, et al. 13. Differential Regulation of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase isozymes; R.K. Sharma, et al. II: Pathophysiological Aspects of Cardiomyopathies. 14. Adriamycin Cardiomyopathy and Its Prevention in an Animal Model; N. Siveski-Iliskovic, et al. 15. Alterations in Sacrolemmal Phospholipid Base Exchange Enzymatic Activities in Diabetic Cardiomyopathy; A. Vecchini, et al. 16. Myocardial Lipid Peroxidation and Diabetes; S.K. Jain. 17. Molecular Biological Changes of Adenine Nucleotide Translocator in J-2-N Cardiomyopathic Hamsters; M. Kato, et al. 18. The Renin&endash;Angiotensin System and the Congenital Cardiomyopathic Hamster; C. Lambert, et al. 19. Dietary Mercury Induces Congestive Cardiomyopathy in the Arctic; I. Asmussen. 20. Peripheral Resistance to Atrial Natriuretic Peptide in Patients with Idiopathic Dilated Cardiomyopathy; G. Iervasi, et al. 21. The Effect of Ethanol on Allylamine-Induced Subendocardial Fibrosis; K. Kato, et al. 22. Nitric Oxide: Friend and Foe in Myocardial Ischemia and Reperfusion; R.C. Kukreya. 23. Role of Leukocytes and Subcellular Abnormalities in Diastolic Dysfunction During Ischemia-Reperfusion; J.S. Juggi, et al. 24. Calcium Channel Blockade Ameliorates Cardiac Dysfunction and Failure in Ischemic Cardiomyopathy; J.M. Capasso. 25. Alterations in Autonomic Nervous System and Heart Mitochondrial Function in Rats Treated with Cyclophosphamide; S. Sugiyama, et al. III: Treatment of Heart Failure. 26. Combined Aerobic and Strength Training in CHF Patients: Pilot Project on Safety and Feasibility; R. Gutierrez, et al. 27. Factors Relating to 6 Minute Walk Performance in Heart Failure Patients; M.C. Hendrican, et al. 28. Dynamic Cardiomyoplasty &endash; The Management of Heart Failure Using Autologous Skeletal Muscle; J.N.K. Odim. 29.