Mechanisms and Emerging Therapies in Tremor Disorders

Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society.  New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.

Giuliana Grimaldi, MD, PhD, is a neurologist.  She is affiliated with Unità Spinale, ASP Palermo, Italy. She is a member of the Society for Cerebellar Research (SRC).

Mario Manto, MD, PhD is a neurologist. He is researcher at the FNRS-Belgium, Head of the Department of Neurology, CHU-Charleroi, and Professor of Neuroanatomy at U Mons.  He is the founding and current editor of the international journal The Cerebellum (Springer). He is the President of the Medical Board of Euro-Ataxia. He has founded the Society for Research on the Cerebellum.  He is editor of the Contemporary Clinical Neuroscience series (Springer).

Autorentext

Giuliana Grimaldi, MD, PhD, is a neurologist. She is affiliated with Unità Spinale, ASP Palermo, Italy. She is a member of the Society for Cerebellar Research (SRC). Mario Manto, MD, PhD is a neurologist. He is researcher at the FNRS-Belgium, Head of the Department of Neurology, CHU-Charleroi, and Professor of Neuroanatomy at U Mons. He is the founding and current editor of the international journal The Cerebellum (Springer). He is the President of the Medical Board of Euro-Ataxia. He has founded the Society for Research on the Cerebellum. He is editor of the Contemporary Clinical Neuroscience series (Springer).