The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.

Volumes 1 and 2 are devoted to cell organization and fate, as well as activities that are autoregulated and/or controlled by the cell environment. Volume 1 examined cellular features that allow adaptation to environmental conditions. Volume 2 begins with a survey of the cell types of the nervous and endocrine systems involved in the regulation of the vasculature and respiratory tract and growth factors. It then describes major cell events in the circulatory and ventilatory systems, such as cell growth, proliferation, migration, and death. Circadian cycles that drive rhythmic gene transcription are also covered.

Describes cell types, functions, and fate in the regulated activities of the circulatory and respiratory systems
Presents applications of mechanics and mathematics for an understanding and prediction of function in health and disease
Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows

Inhalt

Introduction.- 1. Remote Control.- 2. Cell Growth and Proliferation.- 3. Growth Factors.- 4. Cell Survival and Death.- 5. Circadian Clock.- 6. Cell Motility.- Concluding Remarks.- References.- Appendix: NotationsAliases and Symbols.- NotationsPrefixes and Suffixes.- Biochemical, Medical, and Physical Aliases.- Mathematical Symbols, Molecules, and Physical Quantities.- Index.