This symposium was established in 1976 for the purpose of bringing to gether once every two or three years, active investigators in the fore front of contemporary immunology, to present their findings and to discuss their significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the under standing of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptides which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has finally occurred and many applications of these peptides are now being realized. The main symposia topics of the fourth symposium were: T-cell recognition of proteins, structure and function of the T-cell receptor, presentation of protein antigens, recycling and activation of membrane receptor molecules, Ir-gene control of T-cell responses and methods of cell separation. The molecular features recognized by antibodies on proteins were the first immune recognition sites to be local ized and confirmed by synthetic peptides. The complete antigenic structures of several proteins have been defined, and individual antigenic sites have been described on many more proteins. More recently, major breakthroughs have been reported in the immune recognition of proteins by T cells.

Inhalt

The Major Histocompatibility Complex and Protein Recognition by T Lymphocytes.- Murine Ia Genes: Organization, Polymorphism and Heterogeneity.- Intermediates In Class II HLA Antigen Biosynthesis.- Trinitrophenyl Reactive T-Cell Clones in Functional and Molecular Analysis of the HLA-D Region.- T-Cells Recognize Ia Conformation in the Interaction with Antigen Presenting Cells.- T-Cell Recognition and Antigen Presentation of Myoglobin.- T-Cell Recognition and Antigen Presentation of Lysozyme.- The Regions of T-Cell Recognition on the Extracellular Part of the a Chain of Torpedo Californica Acetylcholine Receptor.- Structural Considerations for T-Cell Cognizance of Antigen.- Antigen Presenting Cells: Detection and Quantification of a Cytochrome c Determinant Important for Activation of T Cells on Bone Marrow Derived Macrophages by Using Specific Anti Cytochrome c Monoclonal Antibody.- Antigen Processing and Presentation at a Molecular Level.- The Role of Surface Immunoglobulin in the Processing and Presentation of Antigen.- A Peptide Binding Protein Which Plays a Role in Antigen Presentation.- T-Cell Clones Specific for Synthetic Polypeptides in Cellular Collaborations.- Modulation of T-Cell Functions by Peptide Hormones.- Endosome Acidification and the Pathways of Receptor-Mediated Endocytosis.- Intracellular Traffic of the Mannose 6-Phosphate Receptor and Its Ligands.- Use of Synthetic Peptides in the Delineation of the Role of Non-Antigen Receptors in Mast Cell Signalling Processes.- Structure and Expression of Genes Involved in T Lymphocyte Recognition and Activation.- T-Cell Recognition of Pre-S Regions of HBsAg Can Bypass Nonresponse to the S Region.- Analysis of T-Cell Receptor Gamma Chain Expression in the Thymus.- Production of Suppressor Factor By T-Cells From Mice Immunized with Pneumococcal Polysaccharide.- Auto-Reactive T-Cell Hybridomas and the Role of Foetal Calf Serum.- Cell Anomalies Associated with Spaceflight Conditions.- Human Mononuclear Cell In Vitro Activation In Microgravity and Post-Space Flight.- The Mammalian Heat Shock (Or Stress) Response: A Cellular Defense Mechanism.- Phase Partitioning in Space and on Earth.