Lentiviral Vectors

For the first time a compilation of chapters that depict the biological basis underlying the development of lentiviral vectors, the techniques involved in the manufacture of this new gene delivery tool, and its most promising applications.

Klappentext

For the first time a compilation of chapters that depict the biological bases underlying the development of lentiviral vectors, the techniques involved in the manufacture of this new gene delivery tool, and its most promising applications.

Inhalt

Introduction.-Molecular biology of lentivirus-mediated gene transfer.-HIV-derived lentiviral vectors.-SIV-derived lentiviral vectors.-Non-primate lentiviral vectors.-Production of lentiviral vectors.-Biosafety issues in lentiviral vector production.-Lentiviral vector targeting.-Integration site selection by lentiviruses: biology and possible control.-Improving the posttranscriptional aspects of lentiviral vectors.- Lentiviruses as vectors for CNS diseases.-Lentiviral vectors for the gene therapy of lympho-hematological disorders.-Lentiviral vectors for gene therapy of HIV-induced disease.-Opportunities for the use of lentiviral vectors in human gene therapy.-Subject index