Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies.

Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. Heart Failure: Bench to Bedside thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers.

Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.

Inhalt
Clinical, Physiology and Genetics Changes in Heart Failure.- to Heart Failure.- Cardiac Function in Heart Failure: The Role of Calcium Cycling.- Gene Profiling of the Failing Heart: Epigenetics.- Biochemical and Molecular Changes in Heart Failure.- Bioenergetics and Metabolic Changes in the Failing Heart.- The Mitochondrial Organelle and the Heart.- The Multidimensional Role of Mitochondria in Heart Failure.- Experimental Models of Heart Failure.- Animal Models of Heart Failure.- Signaling, Stress and Cellular Changes in Heart Failure.- Signaling Cascades in Heart Failure: From Cardiomyocytes Growth and Survival to Mitochondrial Signaling Pathways.- Cyclic Nucleotides Signaling (Second Messengers) and Control of Myocardial Function: Effects of Heart Failure.- Calcium Signaling: Receptors, Effectors, and Other Signaling Pathways.- Oxidative Stress and Heart Failure.- Cardiac Remodeling and Cell Death in Heart Failure.- Peripheral Changes and Co-morbid Conditions in Heart Failure.- Heart Failure and Changes at the Periphery: Vascular, Inflammation, Neurohormonal, and Renal Systems.- Comorbidities in Heart Failure.- Heart Failure in Children.- Mechanisms and Clinical Recognition and Management of Heart Failure in Infants and Children.- Mechanical Circulatory Support and Heart Transplantation in Children with Severe Refractory Heart Failure.- Aging and the Failing Heart.- Basic Mechanisms Mediating Cardiomyopathy and Heart Failure in Aging.- Heart Failure of Aging: Clinical Considerations.- Diagnostic Methodology in Heart Failure.- Diagnosis of Heart Failure: Evidence-Based Perspective.- Omics Application in Heart Failure: Novel Diagnostic and Prognostic Markers to Understand Pathophysiology and Find New Therapies.- Available and Forthcoming Therapies for HeartFailure.- Treatment of Chronic Heart Failure.- Gene Therapy in Heart Failure: Forthcoming Therapies.- Myocardial Cell-Based Regeneration in Heart Failure.- Looking to the Future.- Future Frontiers in Heart Failure.