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This title acts as a primer, giving students and newcomers to the
field an opportunity to learn about the breadth of the CNS drug
discovery. The book outlines the core processes in drug discovery
and development for CNS disorders, from evaluating drugs for
desirable efficacy, safety and pharmacokinetic features in
preclinical (using in vitro and in vivo models) and
clinical experimentation to identifying future drug targets.
Containing up-to-date experimental evidence and detailing the main
impediments in the pipeline of CNS drug discovery and development,
this is a key reference for those involved in all stages of CNS
drug discovery.
Key Features:
Discusses in detail the key stages of CNS drug discovery,
outlining the particular requirements and obstacles for CNS
drugs
Addresses safety concerns and future drug targets
Provides succinct background information about the major CNS
diseases
Examples of specific drugs are used throughout to describe the
development of a new drug from conception to clinical use and
post-market surveillance
Primary reasons for drug failure are given for each stage
Autorentext
Dr. John Kelly, Senior Lecturer, Department of Pharmacology and Therapeutics, NUI, Galway, Ireland.
Klappentext
Central Nervous System (CNS) disorders are responsible for a vast range of illnesses, including depression, schizophrenia, Parkinson's disease and Alzheimer's disease. Recent advances in areas such as genome sequencing and molecular biology have improved the potential for breakthrough treatments for these diseases, yet the drug development process for CNS disorders has remained stubbornly slow.
Principles of CNS Drug Development: From Test Tube to Patient outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety and pharmacokinetic features in preclinical (using in vitro and in vivo models) and clinical experimentation to identifying future drug targets. Containing up-to-date experimental evidence and detailing the main impediments in the pipeline of CNS drug discovery and development, this is a key reference for those involved in all stages of CNS drug discovery.
Zusammenfassung
This title acts as a primer, giving students and newcomers to the field an opportunity to learn about the breadth of the CNS drug discovery. The book outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety and pharmacokinetic features in preclinical (using in vitro and in vivo models) and clinical experimentation to identifying future drug targets. Containing up-to-date experimental evidence and detailing the main impediments in the pipeline of CNS drug discovery and development, this is a key reference for those involved in all stages of CNS drug discovery.
Key Features:
Inhalt
Acknowledgements.
Preface.
Abbreviations.
1 Introduction.
1.1 The global burden of CNS disease.
1.2 Assessment of the global burden of disease.
1.3 The prevalence of CNS disorders.
1.4 Disability due to CNS disorders.
1.5 Economic Costs.
1.6 Concluding comments.
References.
2 An overview of the major CNS disorders.
2.1 Introduction.
2.2 Overview of psychiatric disorders.
2.3 Overview of neurological/neurodegenerative disorders.
2.4 Concluding comments.
References.
3 Neurobiological substrates of CNS disorders.
3.1 Introduction.
3.2 Brief introduction to the principles of chemical neurotransmission.
3.3 Stages of chemical neurotransmission.
3.4 Approaches to investigating CNS alterations in CNS disorders.
3.5 Evidence for a neurobiological rationale for CNS disorders.
3.6 Concluding comments.
References.
4 Current pharmacological targets.
4.1 Introduction.
4.2 Pharmacological treatments for depression.
4.3 Pharmacological treatments for schizophrenia.
4.4 Pharmacological treatments for anxiety disorders.
4.5 Pharmacological treatments for epilepsy.
4.6 Pharmacological treatments for Parkinson's disease.
4.7 Pharmacological treatments for Alzheimer's disease.
4.8 Concluding comments.
References.
5 Premarketing efficacy evaluation.
5.1 Introduction.
5.2 Target identification.
5.3 Lead optimisation.
5.4 Target validation in animal models.
5.5 The use of genetically modified animals in CNS drug development.
5.6 A selection of animal models of psychiatric disease.
5.7 A selection of animal models of neurodegenerative disease.
5.8 Which models to choose.
5.9 Clinical trials that evaluate drug efficacy.
5.10 Specific drug profiles.
References.
6 Pharmacokinetic considerations: Absorption, distribution, metabolism and elimination.
6.1 Introduction.
6.2 What are the 'ideal' pharmacokinetic properties for a CNS drug?
6.3 Absorption.
6.4 Distribution.
6.5 Metabolism.
6.6 Elimination.
6.7 Measurement of drug concentrations.
6.8 Factors that affect pharmacokinetics.
6.9 Allometric scaling.
6.10 Microdosing (Phase 0) Studies.
6.11 Dose prediction and therapeutic drug monitoring.
6.12 Stereoselectivity of metabolism of drugs.
6.13 Specific drug profiles.
6.14 Concluding comments.
References.
7 Safety concerns.
7.1 Introduction.
7.2 Postmarketing surveillance.
7.3 Acute poisoning.
7.4 Quantification of the relative risk of fatalities from CNS drugs.
7.5 Adverse drug reactions (ADRs).
7.6 Specific types of toxicity encountered with psychotropic drugs.
7.7 Safety concerns following long-term administration of CNS Drugs.
7.8 Polypharmacy.
7.9 Specific drug profiles.
7.10 Concluding Comments.
References.
Websites.
8 Preclinical and clinical safety evaluation.
8.1 Introduction.
8.2 Preclinical exploratory toxicology and safety pharmacology evaluations.
8.3 Primary and secondary pharmacology.
8.4 Safety pharmacology.
8.5 Toxicology studies required for regulatory purposes.
8.6 Clinical Studies.
8.7 Specific drug profiles.
8.8 Concluding comments.
References.
Websites.
9 CNS drug targets in development and future perspectives.
9.1 Introduction. 9.2 How mu...