Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips.

• Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource.

• Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis.
• Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases.
• Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases.
• Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci.
• PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America.

• Features more than 1,500 high-quality, full-color photographs-with hundreds new to this edition.

  Autorentext

  John E. Bennett, MD, Adjunct Professor of Medicine, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine; Bethesda, Maryland

  Inhalt

  I Basic Principles in the Diagnosis and Management of Infectious Diseases
  A MICROBIAL PATHOGENESIS
  1 A Molecular Perspective of Microbial Pathogenicity
  2 The Human Microbiome of Local Body Sites and Their Unique Biology
  3 Prebiotics, Probiotics, and Synbiotics
  B HOST DEFENSE MECHANISMS
  4 Innate (General or Nonspecific) Host Defense Mechanisms
  5 Adaptive Immunity: Antibodies and Immunodeficiencies
  6 Cell-Mediated Defense Against Infection
  7 Mucosal Immunity
  8 Granulocytic Phagocytes
  9 Complement and Deficiencies
  10 Human Genetics and Infection
  11 Nutrition, Immunity, and Infection
  12 Evaluation of the Patient With Suspected Immunodeficiency
  C EPIDEMIOLOGY OF INFECTIOUS DISEASE
  13 Applied Epidemiology for the Infectious Diseases Physician
  14 Emerging and Reemerging Infectious Disease Threats
  15 Bioterrorism: An Overview
  D CLINICAL MICROBIOLOGY
  16 The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation
  E ANTIINFECTIVE THERAPY
  17 Principles of Antiinfective Therapy
  18 Molecular Mechanisms of Antibiotic Resistance in Bacteria
  19 Pharmacokinetics and Pharmacodynamics of Antiinfective Agents
  20 Penicillins and ß-Lactamase Inhibitors
  21 Cephalosporins
  22 Ertapenem, Imipenem, Meropenem, Doripenem, and Aztreonam
  23 Antibiotic Allergy
  24 Fusidic Acid
  25 Aminoglycosides
  26 Tetracyclines, Glycylcyclines, and Chloramphenicol
  27 Rifamycins
  28 Metronidazole
  29 Macrolides and Clindamycin
  30 Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)
  31 Daptomycin and Quinupristin-Dalfopristin
  32 Polymyxins (Polymyxin B and Colistin)
  33 Linezolid, Tedizolid, and Other Oxazolidinones
  34 Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole
  35 Quinolones
  36 Unique Antibacterial Agents
  37 Urinary Tract Agents: Nitrofurantoin, Fosfomycin, and Methenamine
  38 Topical Antibacterials
  39 Antimycobacterial Agents
  40A Antifungal Agents: Amphotericin B
  40B Antifungal Drugs: Azoles
  40C Antifungal Drugs: Echinocandins
  40D Antifungal Drugs: Flucytosine
  41 Antimalarial Drugs
  42 Drugs for Protozoal Infections Other Than Malaria
  43 Drugs for Helminths
  44 Antiviral Agents: General Principles
  45 Antiviral Drugs for Influenza and Other Respiratory Virus Infections
  46 Antivirals Against Herpesviruses
  47 Antiviral Drugs Against Hepatitis Viruses
  48 Miscellaneous Antiviral Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir, Pleconaril)
  49 Immunomodulators
  50 Hyperbaric Oxygen
  51 Antimicrobial Stewardship
  52 Designing and Interpreting Clinical Studies in Infectious Diseases
  53 Outpatient Parenteral Antimicrobial Therapy
  54 Tables of Antiinfective Agent Pharmacology
  II Major Clinical Syndromes
  A FEVER
  55 Temperature Regulation and the Pathogenesis of Fever
  56 Fever of Unknown Origin
  57 The Acutely Ill Patient With Fever and Rash
  B UPPER RESPIRATORY TRACT INFECTIONS
  58 The Common Cold
  59 Pharyngitis
  60 Acute Laryngitis
  61 Otitis Externa, Otitis Media, and Mastoiditis
  62 Sinusitis
  63 Epiglottitis
  64 Infections of the Oral Cavity, Neck, and Head
  C PLEUROPULMONARY AND BRONCHIAL INFECTIONS
  65 Acute Bronchitis
  66 Acute Exacerbations of Chronic Obstructive Pulmonary Disease
  67 Acute Pneumonia
  68 Pleural Effusion and Empyema
  69 Bacterial Lung Abscess
  70 Chronic Pneumonia
  71 Cystic Fibrosis
  D URINARY TRACT INFECTIONS
  72 Urinary Tract Infections
  E SEPSIS
  73 Sepsis and Septic Shock
  F INTRAABDOMINAL INFECTIONS
  74 Peritonitis and Intraperitoneal Abscesses
  75 Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis)
  76 Pancreatic Infection
  77 Splenic Abscess
  78 Appendicitis
  79 Diverticulitis and Neutropenic Enterocolitis
  G CARDIOVASCULAR INFECTIONS
  80 Endocarditis and Intravascular Infections
  81 Prosthetic Valve Endocarditis
  82 Infections of Nonvalvular Cardiovascular Devices
  83 Prevention of Infective Endocarditis
  84 Myocarditis and Pericarditis
  85 Mediastinitis
  H CENTRAL NERVOUS SYSTEM INFECTIONS
  86 Approach to the Patient With Central Nervous System Infection
  87 Acute Meningitis
  88 Chronic Meningitis
  89 Encephalitis
  90 Brain Abscess
  91 Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis
  92 Cerebrospinal Fluid Shunt and Drain Infections
  I SKIN AND SOFT TISSUE INFECTIONS
  93 Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections
  94 Myositis and Myonecrosis
  95 Lymphadenitis and Lymphangitis
  J GASTROINTESTINAL INFECTIONS AND FOOD POISONING
  96 Syndromes of Enteric Infection
  97 Esophagitis
  98 Diarrhea With Little or No Fever
  99 Acute Dysentery Syndromes (Diarrhea With Fever)
  100 Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers
  101 Foodborne Disease
  102 Tropical Sprue and Environmental Enteric Dysfunction
  K BONE AND JOINT INFECTIONS
  103 Infectious Arthritis of Native Joints
  104 Osteomyelitis
  105 Orthopedic Implant-Associated Infections
  L DISEASES OF THE REPRODUCTIVE ORGANS AND SEXUALLY TRANSMITTED DISEASES
  106 Genital Skin and Mucous Membrane Lesions
  107 Urethritis
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