The immune systems of humans and non-human primates have diverged such that these animals show inter- and intra-species variation in susceptibility, symptoms, and survival of particular infectious diseases. Variation in primate immunity is such that some major human pathogens - such as immunodeficiency viruses, herpesviruses and malaria-inducing species of Plasmodium - elicit striking differences in immune response between closely related species and within populations. Complex evolutionary processes that include interactions among the host, its pathogens and symbiont/commensal organisms have shaped these differences in immunity. The success of some pathogens in establishing persistent infections in humans and other primates has been determined not just by the molecular evolution of the pathogen and its interactions with the host, but also by the evolution of primate behavior and ecology, microflora, immune factors and the evolution of other biological systems.

To explore how interactions between primates and their pathogens have shaped their mutual molecular evolution, Primates, Pathogens and Evolution brings together research that explores comparative primate immune function, the emergence of major and neglected primate diseases, primate-microorganism molecular interactions, and related topics. This book will be of interest to anyone curious as to why infectious diseases manifest differently in humans and their closest relatives. It will be of particular interest to scholars specializing in human and non-human primate evolution, epidemiology and immunology, and disease ecology. Primates, Pathogens and Evolution offers an overview and discussion of current findings on differences in the molecular mechanics of primate immune response, as well as on pathogen-mediated primate evolution and human and non-human primate health.

Zusammenfassung

The immune systems of human and non-human primates have diverged over time, such that some species differ considerably in their susceptibility, symptoms**,** and survival of particular infectious diseases. Variation in primate immunity is such that major human pathogens - such as immunodeficiency viruses, herpesviruses and malaria-inducing species of Plasmodium - elicit striking differences in immune response between closely related species and within primate populations. These differences in immunity are the outcome of complex evolutionary processes that include interactions between the host, its pathogens and symbiont/commensal organisms. The success of some pathogens in establishing persistent infections in humans and other primates has been determined not just by the molecular evolution of the pathogen and its interactions with the host, but also by the evolution of primate behavior and ecology, microflora, immune factors and the evolution of other biological systems.

To explore how interactions between primates and their pathogens have shaped their mutual molecular evolution, Primates, Pathogens and Evolution brings together research that explores comparative primate immune function, the emergence of major and neglected primate diseases, primate-microorganism molecular interactions, and related topics. This book will be of interest to anyone curious as to why infectious diseases manifest differently in humans and their closest relatives. It will be of particular interest to scholars specializing in human and non-human primate evolution, epidemiology and immunology, and disease ecology. Primates, Pathogens and Evolution offers an overview and discussion of current findings on differences in the molecular mechanics of primate immune response, as well as on pathogen-mediated primate evolution and human and non-human primate health.

Inhalt
Acknowledgements.- 1. Primates, pathogens and evolution.- Section I Immunity and Primate Evolution.- 2. Vertebrate Immune system evolution and comparative primate immunity.- 3. Genetic variation in the immune system of Old World monkeys: functional and selective effects.- 4. Toll-like receptor function and evolution in primates.- 5. Impact of natural selection due to malarial disease on human genetic variation.- 6. Parasitic lice help to fill in the gaps of early hominid history.- Section II Emergence and Divergent Disease Manifestation.- 7. Treponema pallidum infection in Primates: Clinical Manifestations, Epidemiology, and Evolution of a Stealthy Pathogen.- 8. Molecular mimicry by -2 herpesviruses to modulate host cell signaling pathways.- 9. Neotropical primates and their susceptibility to Toxoplasma gondii: new insights for an old problem.- 10. The Evolution of SIV in primates and the emergence of the pathogen of AIDS.- Section III Primates, Pathogens and Health.- 11. Microbial exposures and other early childhood influences on the subsequent function of the immune system.- 12. Make new friends and keep the old? Parasite coinfection and comorbidity in Homo sapiens.