In Insulin Resistance: The Metabolic Syndrome X, outstanding investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia (Syndrome X) play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization-as well as polycystic ovary disease. Under the aegis of Gerald Reaven, the discoverer of Syndrome X, the distinguished authorities writing here detail for the first time the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Each author has been encouraged to present a point of view that reflects their unique insights.
The first authoritative book on the subject, Insulin Resistance: The Metabolic Syndrome X illuminates the special importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome. Its thoughtful and detailed approach will make it an essential reference for basic and clinical researchers seeking to understand these critical phenomena.

Klappentext

Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization. These distinguished authorities detail, for the first time, the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Timely and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the full importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome.

Inhalt

Part I. Genetic and Environmental Factors Affecting Insulin Action. Genetics of Insulin Resistance, Michael P. Stern and Braxton D. Mitchell. Ethnic Variation in Insulin Resistance and Risk of Type 2 Diabetes, Paul M. McKeigue. Fetal Effects on Insulin Resistance and Glucose Tolerance,Paul M. McKeigue. Obesity and Insulin Resistance: Epidemiologic, Metabolic, and Molecular Aspects, Jean-Pierre Després and André Marette. The Role of Body Fat Distribution in Insulin Resistance, Abhimanyu Garg. Physical Activity and Insulin Resistance in Man, Flemming Dela, Kári Mikines, and Henrik Galbo. Insulin Resistance in Smokers and Other Long-Term Users of Nicotine, Björn Eliasson and Ulf Smith. Part II. Pathophysiology of Insulin Resistance. Insulin Resistance and Inhibitors of Insulin Receptor Tyrosine Kinase, Jack F.Youngren, Ira D. Goldfine, Vincenzo Trischitta, and Betty A. Maddux. NMR Studies on the Mechanism of Insulin Resistance, Gianluca Perseghin, Kitt Falk Petersen, and Gerald I. Shulman. Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms, Lawrence J. Mandarino. The Role of the Liver in Insulin Action and Resistance, Jerry Radziuk and Susan Pye. The Pathophysiological Consequences of Adipose Tissue Insulin Resistance, Gerald M. Reaven. Insulin Action and Endothelial Function, Alain D. Baron and Michael J. Quon. Part III. Clinical Syndromes Associated with Insulin Resistance. Insulin Resistance and Dyslipidemia: Implications for Coronary Heart Disease Risk, Ami Laws. Insulin Resistance and Blood Pressure, Ele Ferrannini. Microalbuminuria and Insulin Resistance, Jeannie Yip and Roberto Trevisan. PAI-1, Obesity, and Insulin Resistance, Irène Juhan-Vague, Marie-Christine Alessi, and Pierre E. Morange. Insulin Resistance and Cardiovascular Disease, Aaron R. Folsom. Insulin Resistance Effects on Sex Hormones and Ovulation in the Polycystic Ovary Syndrome, John E. Nestler. Index.