In Hormone Resistance Syndromes, leading clinicians review in depth the clinical and molecular aspects of the hormone resistance syndromes caused by receptor mutations. These mutations are involved in a large number of disorders, including dwarfism, Laron syndrome, pseudohypoparathyroidism, insulin resistance, resistance to thyroid hormone, glucocorticoid resistance, hereditary resistance to vitamin D, and estrogen resistance. Throughout, the book's distinguished contributors not only summarize the clinical features of these and related disorders, but also illuminate their molecular bases. In addition to helping discover additional resistance syndromes, readers are afforded a unique opportunity to understand hormone action in normal physiology.
Timely and authoritative, Hormone Resistance Syndromes provides an insightful survey of this critical area, one that will serve as a gold-standard reference for all those clinicians and researchers actively studying these mutations today.

Klappentext

Leading clinicians review in depth the clinical and molecular aspects of the hormone resistance syndromes caused by receptor mutations. These mutations are involved in a large number of disorders, including dwarfism, Laron syndrome, pseudohypoparathyroidism, insulin resistance, resistance to thyroid hormone, glucocorticoid resistance, hereditary resistance to vitamin D, and estrogen resistance. Throughout, the book's distinguished contributors not only summarize the clinical features of these and related disorders, but also illuminate their molecular bases. Hormone Resistance Syndromes provides an authoritative summary and standard reference for all those clinicians and researchers actively studying these mutations today and affords a unique opportunity to understand hormone action in normal physiology.

Inhalt

Dwarfism: GHRH Resistance, Gerhard Baumann and Hiralal G. Maheshwari. Laron Syndrome: Primary Growth Hormone Resistance, Zvi Laron. Pseudohypoparathyroidism, Ali Al-Zahrani, Michael A. Levine, and William F. Schwindinger. Hereditary Resistance to Vitamin D, Peter J. Malloy and David Feldman. Decreased Responsiveness to Extracellular Ca2+ Owing to Abnormalities in the Ca2+O-Sensing Receptor, Edward M. Brown, Olga Kifor, and Mei Bai. Resistance to TSH, Peter Kopp. Thyroid Hormone Resistance, V. Krishna K. Chatterjee, Roderick J. Clifton-Bligh, and Mark Gurnell. Diabetes Mellitus: Insulin Resistance, Simeon I. Taylor and Elif Arioglu. LH Insensitivity Syndrome, Axel P. N. Themmen, John W. M. Martens, and Han G. Brunner. FSH Resistance, Kristina Aittomäki and Ilpo T. Huhtaniemi. Genetic Alterations of Androgen Receptor Function, Ken Brantley, Tianshu Gao, and Michael J. McPhaul. Retained Müllerian Ducts: AMH Resistance Syndrome, Nathalie Josso, Jean-Yves Picard, and Rodolfo Rey. Adrenal Insufficiency: ACTH Resistance, Adrian J. L. Clark. Glucocorticoid Resistance and Hypersensitivity, Denis P. Franchimont and George P. Chrousos. Index.