Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) comprises a group of idiopathic
diseases of the intestine characterized by chronic inflammation of
the bowel with periods of exacerbation and remission. Although the
exact cause of IBD remains undetermined, the condition appears to
be related to a combination of genetic and environmental factors
resulting in an aberrant activation of the mucosal immune system.
This book contains a series of interdisciplinary discussions
between clinical and basic scientists focusing on key issues such
as:

• Epithelial cell and molecular biology, including apoptosis,
  necrosis and cell survival

• The role of bacterial milieu and mucosal bacteria in the IBD
  and of prebiotic and probiotic therapy

• The progress towards the identification of susceptibility genes
  and phenotype-determining genes

• The pharmacogenetics of IBD

• Mucosal immunology and therapeutic strategies stemming
  therefrom

Autorentext

Derek J. Chadwick and Jamie A. Goode are editors for Inflammatory Bowel Disease: Crossroads of Microbes, Epithelium and Immune Systems and other scientific titles.

Klappentext
Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. The two major categories of IBD are ulcerative colitis and Crohn's disease. In their classical forms, they differ both clinically and histologically but it is still uncertain whether they are distinct diseases. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors that result in aberrant activation of the mucosal immune system. Whilst chemotherapeutic treatments are usually effective in most patients in maintaining prolonged remission and decreasing the length of active disease periods, such treatments have side effects and a significant number of people still require surgery.

This important book draws together four fundamental strands in IBD research: genetics, bacteriology, epithelial biology and immunology. The identification of genes that confer susceptibility to IBD is likely to translate into a more detailed and complete understanding of disease pathogenesis and of the nature of the key interactions with environmental insults. This could lead to better diagnosis and more rational and appropriate treatment.

Inhalt
Chair's Introduction (Jewell). Progress toward identifying inflammatory bowel disease susceptibility genes (Rioux).

Phenotype-determining genes in inflammatory bowel disease (Ahmad).

Pharmacogenetics of inflammatory bowel disease (Kelleher et al).

Bacterial milieu and mucosal bacteria in ulcerative colitis (Macfarlane et al).

Defensins and mucosal protection (Mahid and Cunliffe).

Intestinal mycoplasma in Crohn's Disease (Roediger).

Kong Probiotics, prebiotics and antibiotics in inflammatory bowel disease (Cummings and Choon).

The eipthelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption (Ivanov et al).

Apoptosis or necrosis - colonic epithelial cell survival (Gibson).

Genetic aspects of intestinal permeability in inflammatory bowel disease (Takeuchi et al).

Animal models of intestinal inflammation: clues to the pathogenesis of inflammatory bowel disease (Powrie and Uhlig).

Homing of intestinal immune cells (Uhlig et al).

Anti-TNF therapy in Crohn's Disease (Ghosh).

Index of contributors.

Subject index.