Critically ill patients are at risk for a higher frequency and severity of adverse drug events (ADEs), and special patient populations of the critically ill - requiring for instance individualized dosing due to non-average weight, hepatic or renal dysfunction, extracorporeal circulation devices, advanced age, pharmacogenetic alterations, hemodynamic instability, or therapeutic hypothermia - are particularly challenging. A contributing factor to this is the use of high-risk medications with many administered intravenously (IV). Hypervigilant monitoring of high-risk medications is still essential to prevent patient harm, especially in populations that have dosing challenges, hence, regulatory bodies internationally require active institutional surveillance of high-risk medications. These dosing challenges are a great safety concern, since there is considerable risk of unwanted adverse drug events from overdosing or therapeutic inefficacy from underdosing.
High-Risk IV Medications in Special Patient Populations reviews high-risk IV medication dosage considerations for special patient populations and discusses the safety concerns of these medications to aid the clinician in cautious monitoring. The authors provide clinicians with tools to minimize adverse drug events with IV high-risk medications, while maximizing the beneficial clinical effects of these drugs, thus making this book essential reading for all involved with the care of critically ill patients.

Zusammenfassung
Critical Care Clinicians can use general drug references (Micomedex, Lexicomp) for data on dosing of high-alert medications in special patient populations but these references are not available to all healthcare clinicians, they are expensive and they are not specific to high-alert medications or critically ill patients. Doctors, nurses and pharmacists in the hospital setting will benefit from having one resource with all of this information. The purpose of this reference manual would be to guide critical care clinicians on dosing of high-alert medications in special patient populations. The most important feature of the book will be a summary of primary literature using tables when possible. This will be useful to readers because currently a reference book does not exist that guides clinicians in these difficult dosing decisions.

Inhalt
Anesthetic agents (general, inhaled, intravenous).- Propofol, ketamine, etc.- Anti-infectives.- aminoglycosides, vancomycin, drotrecogin, amphotericin products.- inhaled agents.- Anticoagulants agents.- unfractionated heparin, low molecular weight heparins, fondaparinux, lepirudin, argatroban, bivalrudin, abciximab, eptifibatide, tirofiban.- Thrombolytics reteplase, tenecteplase, streptokinase, urokinase, alteplase.- Cardiac Drugs.- Adrenergic agents.- dopamine, dobutamine, vasopressin, , nitroglycerin, nitroprusside epinephrine, norepinepherine, phenylepherine.- Adrenergic antagonists.- Propranolol, diltiazem, verapamil, esmolol, labetalol, clevidipine.- Antidyrrhthmics.- amiodarone, lidocaine, procainamide.- Inotropic agents.- milrinone, amrinone, isoproterenol, niseritide, digoxin.- Prostanoids.- Epoprostenol, iloprost, treprostenil.- Electrolytes.- Potassium, magnesium, sodium chloride (hypertonic), cardioplegic solutions.- Hypoglycemics.- Insulin and oral agents.- Neuromuscular blocking agents .- vecuronium, rocuronium, cisatracurium, atracurium, succinylcholine.- Opioids (IV, oral).- Remifentanyl, fentanyl , morphine, hydromorphone, meperidine.- Sedatives (IV, oral and transdermal).- lorazepam, midazolam, diazepam, propofol, dexmedetomidine.- Information for Each Drug.- Propofol .- Normal.- Obese.- Renal Dysfunction.- CrCL.- Dialysis (HD, CRRT).- Liver Dysfunction.- Recommendations for Safe Use.