Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics, the various impacts of designing new strategies, and identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and to all who are interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.

Autorentext

Heide Schatten is Professor at the University of Missouri, Columbia, USA. She is a cell biologist with research focused on cytoskeletal regulation in various cell systems and on cytoskeletal dysfunctions that play a role in disease such as cancer.

Her interest in cancer research was stimulated by father and sister physicians who as clinicians were faced with treating incurable diseases for which research on cell and molecular levels had not yet advanced to our current state of knowledge. She pursued her interest in research and received her M.S. and Ph.D. degrees from the Karl-Ruprecht University in Heidelberg, Germany, and performed her Ph.D. research studies at the German Cancer Research Center in Heidelberg to explore the mechanisms leading to abnormal cell divisions in cancer and to test drugs that prevent abnormal cell proliferation. She performed pre-and postdoctoral studies at the University of California, Berkeley, and entertained numerous collaborations with colleagues in the USA, Canada, Europe, China, and Latin America in the fields of reproduction and cancer using cell and molecular biology approaches. She has given numerous presentations in these and other countries. Her studies also included collaborations with NASA scientists and experiments aboard the Space Shuttle Endeavour to examine the effects of spaceflight on centrosome-cytoskeletal regulation during development. She also holds an M.S. degree in music from the School of Music in Heidelberg.

She is a member of the American Society for Cell Biology, American Association for the Advancement of Science, and Microscopy Society of America. She has received numerous awards including grant awards from NASA, NIH, and NSF. She has published over 210 papers, 13 book chapters and edited several special topics journal issues and 9 books with several more in progress.

Inhalt

1. Histopathology and grading of breast cancer.- 2. Multicentric/multifocal breast cancer: overview, biology and therapy.- 3. The immune system in breast cancer initiation and progression: role of epithelial to mesenchymal transition.- 4. Remodeling of the extracellular matrix: implications for cancer.- 5. Biology and treatment of basal-like breast cancer.- 6. Re-excision after lumpectomy for breast cancer.- 7. Novel anti-angiogenic therapies using naturally-occurring and synthetic drugs to combat progestin-dependent breast cancer.- 8. New insights on estrogen receptor actions in hormone-responsive breast cancer cells by interaction proteomics.- 9. Reprogramming breast cancer cells with embryonic microenvironments: insights from nodal signaling.- 10. Metastatic determinants: breast tumour cells in circulation.- 11. Breast cancer epigenetics: biomarkers and therapeutic potential.- 12. The impact of centrosome abnormalities on breast cancer development and progression with a focus on targeting centrosomes for breast cancer therapy.- 13. A New Perspective on Cyclin D1: beyond cell cycle regulation.- 14. Gene signatures of inflammatory breast cancer: epithelial plasticity and a cancer stem cell phenotype.- 15. An integrated human mammary epithelial cell culture system for studying carcinogenesis and aging.- 16. New breast cancer treatment considerations a brief review of the use of genetically modified (attenuated) bacteria as therapy for advanced and metastatic breast cancer.