The quest to harness the immune system for the treatment of cancer has been of great interest for more than 100 years, but new discoveries illuminating the requirements for immune activation and recognition of cancers have greatly increased the promise of reaching this goal. In Handbook of Cancer Vaccines, leading scientific investigators and clinicians distill the vast body of literature on cancer vaccines to create an authoritative survey of the scientific background for such therapeutic vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that affect all vaccines (such as immune adjuvants and prime-boost strategies), describe cutting-edge methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. Topics of particular interest include the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers, the monitoring of biologic responses to these vaccines, and the statistical and regulatory issues affecting the design and conduct of their clinical trials.
Comprehensive and authoritative, the Handbook of Cancer Vaccines makes available to medical oncologists and immunologists a cutting-edge synthesis of the scientific rationale, preclinical data, and clinical results for the powerful new generation of vaccines now under development for the treatment of a wide range of human cancers.

Klappentext

An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

Inhalt

Part I: Basic Science of Tumor Antigens and Immune Activation Biology of the Cancer Vaccine Immune Response Michael A. Morse, Timothy M. Clay, and H. Kim Lyerly The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity John Fikes Identification of Tumor Antigens Using Subtraction and Microarrays Jiangchun Xu Tumor Antigen Discovery With T Cells Paul F. Robbins Targeting Viral Antigens for the Treatment of Malignancies Gretchen L. Eiben, Diane M. Da Silva, Steven C. Fausch, Amanda M. Krier, I. Caroline Le Poole, Megan E. Papineau, Michael I. Nishimura, and W. Martin Kast Immune Defects in Cancer Dmitry Gabrilovich and Vladimir Pisarev Escape of Tumors From the Immune System: Role of the Transforming Growth Factor-b-Signaling Pathway Gerard C. Blobe Part II: General Vaccine and Immunotherapy Strategies Immune Adjuvants Jory R. Baldridge, Susan Hand Zimmermann, and Sally P. Mossman Heterologous Prime-Boost Vaccination in Tumor Immunotherapy Michael J. Palmowski and Caroline Smith Peptide-Based Vaccines Carmen M. Berger, Keith L. Knutson, Lupe G. Salazar, Kathy Schiffman, and Mary L. Disis Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens Govind Ragupathi, John Gathuru, and Philip O. Livingston Anti-Idiotype Vaccines Sunil K. Chatterjee, Malaya Bhattacharya-Chatterjee, and Kenneth A. Foon Pox Viral Vaccines James L. Gulley, Philip M. Arlen, and Jeffrey Schlom Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches Zachary Hartman and Andrea Amalfitano Alphaviral-Based Strategies for the Immunotherapy of Cancer Edward L. Nelson and Jonathan Smith DNA Vaccines Michael Bereta and Howard L. Kaufman Whole-Cell Vaccines Timothy M. Clay, Paul J. Mosca, H. Kim Lyerly, and Michael A. Morse Gene-Modified Tumor-Cell Vaccines Leisha A. Emens and Elizabeth M. Jaffee Hapten-Modified Tumor Vaccines David Berd Chaperone Proteins/Heat Shock Proteins As Anticancer Vaccines Michael W. Graner and Emmanuel Katsanis Dendritic Cell Vaccines Madhav V. Dhodapkar Exosomes for Immunotherapy of Cancer Nathalie Chaput, N. E. C. Schartz, Fabrice Andre, and Laurence Zitvogel Immunocytokines for Cancer Immunotherapy Paul M. Sondel and Steven D. Gillies T-Cell Adoptive Immunotherapy Gregory E. Plautz, Peter A. Cohen, David E. Weng, and Suyu Shu Part III: Tumor-Specific Vaccine Development Melanoma Vaccines Jeffrey Weber Allogenic Melanoma Lysate Vaccines Malcolm S. Mitchell Renal Cancer Vaccines Hyung L. Kim, Barbara J. Gitlitz, and Robert A. Figlin Vaccines for Hematological Malignancies Qing Yi Vaccines for the Immunotherapy of Prostate Cancer Boris Minev and Michael L. Salgaller Vaccine Therapy for Breast and Ovarian Cancers Susan E. Smith and Alison T. Stopeck Vaccine Therapy for Gastrointestinal Cancers John L. Marshall Vaccines for Lung Cancer Michael A. Morse, Jennifer Garst, and Eric Toloza Vaccines for Other Tumors Michael A. Morse Part IV: Clinical Trials and Immune Analyses Clinical Trial Designs for Therapeutic Vaccine Studies Richard Simon Analysis of Cellular Immune Responses in Cancer Vaccine Trials Timothy M. Clay, Michael A. Morse, Paul J. Mosca, Amy Hobeika, Donna Niedzwiecki, and H. Kim Lyerly Analysis of Humoral Immune Responses in Vaccine Trials Rajasekharan Somasundaram, Tianqian Zhang, and Dorothee Herlyn Regulatory Issues Affecting Tumor Vaccines Mark O. Thornton, Alexand