An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

Includes supplementary material: sn.pub/extras

Klappentext

The quest to harness the immune system for the treatment of cancer has been of great interest for more than 100 years, but new discoveries illuminating the requirements for immune activation and recognition of cancers have greatly increased the promise of reaching this goal. In Handbook of Cancer Vaccines, leading scientific investigators and clinicians distill the vast body of literature on cancer vaccines to create an authoritative survey of the scientific background for such therapeutic vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that affect all vaccines (such as immune adjuvants and prime-boost strategies), describe cutting-edge methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. Topics of particular interest include the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers, the monitoring of biologic responses to these vaccines, and the statistical and regulatory issues affecting the design and conduct of their clinical trials.
Comprehensive and authoritative, the Handbook of Cancer Vaccines makes available to medical oncologists and immunologists a cutting-edge synthesis of the scientific rationale, preclinical data, and clinical results for the powerful new generation of vaccines now under development for the treatment of a wide range of human cancers.

Inhalt
I: Basic Science of Tumor Antigens and Immune Activation.- 1 Biology of the Cancer Vaccine Immune Response.- 2 The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity.- 3 Identification of Tumor Antigens Using Subtraction and Microarrays.- 4 Tumor Antigen Discovery With T Cells.- 5 Targeting Viral Antigens for the Treatment of Malignancies.- 6 Immune Defects in Cancer.- 7 Escape of Tumors From the Immune System: Role of the Transforming Growth Factor-ß-Signaling Pathway.- II: General Vaccine and Immunotherapy Strategies.- 8 Immune Adjuvants.- 9 Heterologous Prime-Boost Vaccination in Tumor Immunotherapy.- 10 Peptide-Based Vaccines.- 11 Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens.- 12 Anti-Idiotype Vaccines.- 13 Pox Viral Vaccines.- 14 Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches.- 15 Alphaviral-Based Strategies for the Immunotherapy of Cancer.- 16 DNA Vaccines.- 17 Whole-Cell Vaccines.- 18 Gene-Modified Tumor-Cell Vaccines.- 19 Hapten-Modified Tumor Vaccines.- 20 Chaperone Proteins/Heat Shock Proteins As Anticancer Vaccines.- 21 Dendritic Cell Vaccines.- 22 Exosomes for Immunotherapy of Cancer.- 23 Immunocytokines for Cancer Immunotherapy.- 24 T-Cell Adoptive Immunotherapy.- III: Tumor-Specific Vaccine Development.- 25 Melanoma Vaccines.- 26 Allogenic Melanoma Lysate Vaccines.- 27 Renal Cancer Vaccines.- 28 Vaccines for Hematological Malignancies.- 29 Vaccines for the Immunotherapy of Prostate Cancer.- 30 Vaccine Therapy for Breast and Ovarian Cancers.- 31 Vaccine Therapy for Gastrointestinal Cancers.- 32 Vaccines for Lung Cancer.- 33 Vaccines for Other Tumors.- IV: Clinical Trials and Immune Analyses.- 34 Clinical Trial Designs for Therapeutic Vaccine Studies.- 35 Analysis of Cellular ImmuneResponses in Cancer Vaccine Trials.- 36 Analysis of Humoral Immune Responses in Vaccine Trials.- 37 Regulatory Issues Affecting Tumor Vaccines.