Genome Stability and Human Diseases

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting 'bottlenecks' in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.

This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Inhalt
Robert P. Fisher, Coming full circle: Cyclin-dependent kinases as anti-cancer drug targets. Stephen Rea, Histone modifications in normal development and disease. Thomas Costelloe and Noel F. Lowndes, Both chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56. David M. S. Pinto and Andrew Flaus, Structure and function of histone H2AX. Helmut Pospiech, Frank Grosse, and Francesca Pisani, The initiation step of eukaryotic DNA replication. Torsten Krude, Non-coding RNAs: New players in the field of eukaryotic DNA replication. Sokka Miiko, Parkkinen Sinikka, Helmut Pospiech, and Juhani E. Syväoja, Function of TopBP1 in genome instability. Sandra Broderick, Kristina Rehmet, Claire Concannon, and Heinz-Peter Nasheuer, Eukaryotic single-stranded DNA binding proteins and genomic stability. Emmanuele Crespan, Alessandra Amoroso, and Giovanni Maga, DNA polymerases and mutagenesis in human cancers. Séverine Cruet-Hennequart, Kathleen Gallagher, Anna M. Sokol, Sangamitra Villalan, Áine M. Prendergast, and Michael P. Carty, DNA polymerase h , a key protein in translesion synthesis in human cells. William C. Copeland, The Mitochondrial DNA Polymerase in Health and Disease. Macdara Glynn, Agnieszka Kaczmarczyk, Lisa Prendergast, Nadine Quinn, and Kevin F. Sullivan, Chromosome segregation and genome instability. N. I. Rechkunova and O. I. Lavrik, Nucleotide excision repair in higher eukaryotes: Mechanism of primary damage recognition in global genome repair. Michael R. Lieber, Jiafeng Gu, Haihui Lu, Noriko Shimazaki, and Albert G. Tsai, Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans. Michael Böhringer and Lisa Wiesmüller, Fluorescence-based quantification of pathway-specific DSB repair activities: a powerful method for the analysis of genome destabilizing mechanisms. ChiaraMondello and A. Ivana Scovassi, Apoptosis: a way to prevent genome instability. Sarah Conmy and Heinz-Peter Nasheuer, The use of transgenic mice in cancer and genome stability research.