This book evaluates trends arising in "-Omics" sciences in terms of their current and potential future application to therapeutic design and understanding of disease. Chapters consider the impact of pharmacogenomics and bioinformatics on drug development, as well as trends in genomics, as applied to understanding of neurodegenerative and lung disease, psychiatry and oncology. Following the genome studies released in early part of this century, the advent of the -Omics sciences (genomics and pharmacogenomics, proteomics, metabolomics, transcriptomics) has seen the expansion of a vast knowledgebase with utility in preventing and treating disease, and improving health for all. Bioinformatics and improved pharmacogenetic understanding forge a path for improved drug discovery and design methods accounting for differences in delivery and disposition across populations.

Autorentext

Dr Yashwant Pathak is the Associate Dean for Faculty Affairs and Full Professor in the College of Pharmacy, Morsani College of Medicine and College of Public Health at the University of South Florida (USF). He is an internationally recognized scholar, researcher and educator in the areas of health care education, nanotechnology, drug delivery systems and nutraceuticals.

Dr Pathak was awarded his MPharm and PhD from Nagpur University, India. He also holds an Executive MBA and Masters in Conflict Management from Sullivan University, Louisville, USA. His post-doctoral training was at Royal free Hospital London, UK, Hebrew University of Jerusalem, Israel and University of Michigan Medical Center at Ann Arbor, Michigan, USA. In addition to his primary roles, Dr Pathak is also Professor at  USF College of Social and Behavioral Sciences and USF College of Sustainability; Adjunct Professor at JSS University Mysore, India; holds adjunct appointments at the University of West Indies Arthur Lok Jack Graduate School of Business, Trinidad And Tobago, and the College of Business at USF for DBA programs; and is a member of the Advisory Board for NERC (Nanotechnology Education and Research Centre) College of Engineering, USF. Prior to these current appointments, he gained 9 years of experience as Dean at USF and 17 years as faculty and researcher. He has also worked as Chair of the International Working group for USF Health and Director of the Nano Center.

Dr Pathak has over 150 research publications and over 22 edited books. He has presented his work in more than 100 national and international conferences. In the last two years he has been awarded the Fulbright Senior Scholar Core Fellowship Award 2015-2016 for Indonesia; the Endeavour Executive fellowship by Australian Government 2015 in collaboration with Deakin University; the CNPQ Brazil Government Fellowship; the Outstanding Achievement Award for Global Engagement by USF; the Outstanding faculty Award for USF March 2017; and been made a Fellow of NSF I-Corps USF 2016.

Klappentext

This book evaluates trends arising in -Omics sciences in terms of their current and potential future application to therapeutic design and understanding of disease. Chapters consider the impact of pharmacogenomics and bioinformatics on drug development, as well as trends in genomics, as applied to understanding of neurodegenerative and lung disease, psychiatry and oncology. Following the genome studies released in early part of this century, the advent of the -Omics sciences (genomics and pharmacogenomics, proteomics, metabolomics, transcriptomics) has seen the expansion of a vast knowledgebase with utility in preventing and treating disease, and improving health for all. Bioinformatics and improved pharmacogenetic understanding forge a path for improved drug discovery and design methods accounting for differences in delivery and disposition across populations.

Inhalt

Chapter 1. Rethinking drug discovery and targeting after the genomic revolution

Dharmesh R Chejara, Ravindra V Badhe, Pradeep Kumar, Yahya E Choonara, Lomas K Tomar, Charu Tyagi, Viness Pillay

Chapter 2. Living between sickness and health: Where is the human genome leading us?

Amy Broadwater, Yashwant Pathak

Chapter 3. Pharmacogenomics: Setting Newer Paradigms of Genetics in Therapy and Medicine

Sanjay Dey, Kumud Joshi, Bhaskar Mazumder

Chapter 4. Bioinformatics and Pharmacogenomics: Tools to Understand and Accelerate Infectious Disease Control Ashwani sharma, Subrata Sinha, Surabhi Johari, Bhaskar Mazumder

Chapter 5. Race and Ethnicity Understanding Difference in the Genome Era

Shannon Kelly, Yashwant Pathak

Chapter 6. The Food Metabolome and Novel Dietary Biomarkers Associated with Diseases

Orhan E Arslan, Philip Palmon

Chapter 7. Impact of genomics on drug discovery and clinical medicine

Deepak Gupta

Chapter 8. Genomics and drug transporters and application in drug discovery, delivery and development

Robert Gharavi, Hazem E. Hassan

Chapter 9. Genomics and drug metabolizing enzymes its application in Drug delivery: Evaluating the influence of the microbiome

Sheeba Varghese Gupta

Chapter 10. Essentials of Genomics in the Continuum of Translational Research

Sadaf Aslam

Chapter 11. Charting a course for genomic medicine from base pair to bedside

Teresa Vo

Chapter 12. Pharmacogenomics and pharmacoepigenomics: impact on therapeutic strategies

Kristopher R Hall, Tamer E. Fandy

Chapter 13. Clinical Pharmacogenomics and Personalized Medicine: New strategies to maximize drug efficacy and avoid adverse drug reaction

Chonlaphat Sukasem, Sadeep Medhasi

Chapter 14. Epigenetic Patterns/Therapies associated with Genetic Disorders

Mazzio Elizabeth, Soliman KFA

Chapter 15. Neurodegenerative disease conditions and genomic treatment  for better health

Ravindra V. Badhe, Dharmesh R. Chejara, Pradeep Kumar, Yahya E. Choonara, Viness Pillay

Chapter 16. Recent Trends in -Omics based methods and techniques for Lung Diseases prevention

Raisah Salhab, Yashwant V Pathak

Chapter 17. Impact of Genomics on Personalization of Breast Cancer Care

F. Scott Heinemann, Alice Police, Erin Lin, Mandy Liu, Sherry Liang, Ying Huang

Chapter 18. Pharmacogenomics: a new approach for preventing severe cutaneous adverse drug reactions

Chonlaphat Sukasem, Therdpong Tempark